Categories
  • Medication side effects
    •   Encyclosphere.org ENCYCLOREADER
      supported by EncyclosphereKSF

    List of side effects of doxepin

    From Wikipedia - Reading time: 3 min

    The antidepressant drug doxepin has been associated with a number of different adverse effects, including the following.[1][2][3]

    The incidence of these adverse effects is not totally known as the scarcity of well-designed clinical trials involving doxepin prohibits it. Side effects that are common (based on its pharmacology or the frequency of these side effects with related agents) appear with a * superscript whereas the serious side effects are in bold. Doxepin is licensed to be used in much smaller doses (viz., 3mg and 6 mg) in some countries, the side-effects profile of which may differ from this list.

    • Nausea*
    • Dizziness*
    • Drowsiness*
    • Dry mouth*
    • Constipation*
    • Blurred vision*
    • Headache*
    • Urinary hesitancy*
    • Agitation*
    • Hypotension (low blood pressure)
    • Hypertension (high blood pressure)
    • Tachycardia (high heart rate)
    • Skin rash
    • Facial oedema
    • Photosensitisation
    • Urticaria (hives)
    • Pruritus (itching)
    • Indigestion
    • Bone fractures
    • Taste disturbances
    • Diarrhoea
    • Anorexia (weight loss)
    • Aphthous stomatitis (canker sores)
    • Gynaecomastia (swelling of the breasts in men)
    • Galactorrhoea (lactation that is unassociated with breast feeding or pregnancy)
    • Chills
    • Fatigue
    • Weakness
    • Flushing
    • Alopecia (hair loss)
    • Eosinohpilia
    • Blood dyscrasias (abnormalities in the cellular composition of blood)
    • Increased liver function tests
    • Hyperpyrexia (high fever ≥41.5 °C or 106.7 °F)
    • Seizures
    • Confusion
    • Malaise
    • Increased appetite*
    • Changes in ECG parameters (e.g. QRS & PR interval)
    • Ataxia
    • Hallucinations
    • Paraesthesias
    • Nervousness
    • Numbness
    • Tinnitus
    • Hepatitis (liver swelling)
    • Exacerbation of asthma
    • Hepatic (liver) abnormalities
    • Urinary retention
    • Extrapyramidal symptoms
    • Testicular swelling
    • Hyperglycaemia (high blood sugar)
    • Hypoglycaemia (low blood sugar)
    • Hyponatraemia (low blood sodium)
    • Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
    • Closed-angle glaucoma
    • Alzheimer's disease or dementia* [4]

    References

    [edit]
    1. ^ "Sinepin Capsules 25mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Marlborough Pharmaceuticals Ltd. 22 September 2011. Retrieved 3 December 2013.
    2. ^ "Deptran Doxepin (as hydrochloride)" (PDF). TGA eBusiness Services. Alphapharm Pty Ltd. 6 May 2013. Retrieved 3 December 2013.
    3. ^ "Silenor (doxepin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 December 2013.
    4. ^ Gray, Shelly L.; Anderson, Melissa L. (January 26, 2015). "Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study". JAMA Intern. Med. 175 (3): 401–7. doi:10.1001/jamainternmed.2014.7663. PMC 4358759. PMID 25621434. Retrieved January 27, 2015.
    This article is licensed under CC BY-SA 3.0.
    Original source: https://en.wikipedia.org/wiki/List of side effects of doxepin
    Status: article is cached
    Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF