NUDT12

NUDT12
Identifiers
Aliases	NUDT12, nudix hydrolase 12
External IDs	OMIM: 609232 MGI: 1915243 HomoloGene: 44188 GeneCards: NUDT12
Gene location (Human)
Chr.	Chromosome 5 (human)
End	103,562,790 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	59,320,367 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; jejunal mucosa; ; rectum; ; Achilles tendon; ; body of pancreas; ; vastus lateralis muscle; ; Left adrenal gland; ; retinal pigment epithelium; ; duodenum; ; right lobe of liver;
	Top expressed in
	left lobe of liver; ; kidney; ; brown adipose tissue; ; intercostal muscle; ; adrenal gland; ; white adipose tissue; ; proximal tubule; ; myocardium of ventricle; ; substantia nigra; ; Epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	NAD+ diphosphatase activity; protein binding; hydrolase activity; metal ion binding; NADH pyrophosphatase activity;
Cellular component	cytoplasm; peroxisome; nucleus; peroxisomal matrix; cytosol;
Biological process	NAD catabolic process; NADP catabolic process; NAD biosynthesis via nicotinamide riboside salvage pathway; NADH metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	83594
	67993
	ENSG00000112874
	ENSMUSG00000024228
	Q9BQG2
	Q9DCN1
	NM_001300741; NM_031438
	NM_026497; NM_001368393
	NP_001287670; NP_113626
	NP_080773; NP_001355322
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.^[5]^[6]

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors.

Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003).[supplied by OMIM]^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112874 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024228 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ ^a ^b "Entrez Gene: NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12".

Further reading[edit]

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Abdelraheim SR, Spiller DG, McLennan AG (2003). "Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein". Biochem. J. 374 (Pt 2): 329–35. doi:10.1042/BJ20030441. PMC 1223609. PMID 12790796.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112874 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024228 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12".

[1]

[2]

[3]

[4]

[5]

[6]