Phosphatidylinositol 3-kinase-related kinase

Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks).^[1]

Members[edit]

The human PIKK family includes six members:

Gene	Protein	Function
ATM	ataxia-telangiectasia mutated	response to DNA damage
ATR	ataxia- and Rad3-related	"
PRKDC	DNA-dependent protein kinase catalytic subunit (DNA-PKcs)	"
MTOR	mammalian target of rapamycin (mTOR)	nutrient-regulated kinase that controls metabolism and cell growth
SMG1	suppressor of morphogenesis in genitalia	regulates nonsense-mediated mRNA decay
TRRAP	transformation/transcription domain-associated protein	transcription factor co-activator

Structure[edit]

PIKKs proteins contain the following four domains:

N-terminus FRAP-ATM- TRRAP (FAT) domain, Pfam PF02259
kinase domain (KD; PI3_PI4_kinase),
PIKK- regulatory domain (PRD), and
C-terminus FAT-C-terminal (FATC) domain Pfam PF02260

References[edit]

^ Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". EMBO J. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC 2752028. PMID 19779456.

External links[edit]

Kinase Family PIKK at WikiKinome.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid19779456-1] Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". EMBO J. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC 2752028. PMID 19779456.

[1]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)