Categories
  • 4,5-Epoxymorphinans
  • Semisynthetic opioids
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    RAM-378

    From Wikipedia - Reading time: 7 min
    RAM-378
    Identifiers
    IUPAC name
    • 3,6,14-trihydroxy-4,5α-epoxy-17-(2-phenylethyl)morphinan
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC24H27NO4
    Molar mass393.483 g·mol−1
    3D model (JSmol)
    SMILES
    • C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3CCC6=CC=CC=C6)[C@H]([C@H]1O)OC5=C(C=C4)O)O
    InChI
    • InChI=1S/C24H27NO4/c26-17-7-6-16-14-19-24(28)10-8-18(27)22-23(24,20(16)21(17)29-22)11-13-25(19)12-9-15-4-2-1-3-5-15/h1-7,18-19,22,26-28H,8-14H2/t18-,19+,22-,23-,24+/m0/s1
    • Key:GAHRZWMAHDWVCL-VKJMTUIMSA-N
      (verify)

    RAM-378[1](7,8-Dihydro-14-hydroxy-N-phenethylnormorphine) is an opioid analgesic. It is the N-phenethyl derivative of hydromorphinol.

    See also

    [edit]
    • 14-Cinnamoyloxycodeinone
    • 14-Phenylpropoxymetopon
    • 7-PET
    • N-Phenethylnormorphine
    • N-Phenethyl-14-ethoxymetopon
    • Phenomorphan
    • Ro4-1539

    References

    [edit]
    1. ^ Ben Haddou T, Béni S, Hosztafi S, Malfacini D, Calo G, Schmidhammer H, Spetea M (2014). "Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity". PLOS ONE. 9 (6): e99231. Bibcode:2014PLoSO...999231B. doi:10.1371/journal.pone.0099231. PMC 4053365. PMID 24919067.


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