SFSWAP

SFSWAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5Z, 2E60
Identifiers
Aliases	SFSWAP, SFRS8, SWAP, splicing factor SWAP homolog, splicing factor SWAP
External IDs	OMIM: 601945; MGI: 101760; HomoloGene: 134548; GeneCards: SFSWAP; OMA:SFSWAP - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	131,799,738 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	129,648,448 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tendon of biceps brachii; ; olfactory bulb; ; internal globus pallidus; ; external globus pallidus; ; beta cell; ; right hemisphere of cerebellum; ; pars reticulata; ; cardia; ; left ovary;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; ventricular zone; ; zygote; ; cerebellar cortex; ; superior frontal gyrus; ; primary visual cortex; ; granulocyte; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	nucleus;
Biological process	mRNA processing; RNA processing; negative regulation of mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; alternative mRNA splicing, via spliceosome; transcription, DNA-templated; RNA splicing; mRNA 5'-splice site recognition;
	Sources:Amigo / QuickGO
Orthologs
	6433
	231769
	ENSG00000061936
	ENSMUSG00000029439
	Q12872
	Q3USH5
	NM_001261411; NM_004592; NM_152235
NM_001035259; NM_172276; NM_001359952; NM_001378915; NM_001378916;
	NM_001378917
	NP_001248340; NP_004583
	NP_758480; NP_001346881; NP_001365844; NP_001365845; NP_001365846
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, suppressor of white-apricot homolog is a protein in humans that is encoded by the SFSWAP gene.^[5]

This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000061936 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029439 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Splicing factor, suppressor of white-apricot homolog (Drosophila)". Retrieved 2013-05-08.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Splicing factor, suppressor of white-apricot homolog (SFSWAP)

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000061936 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029439 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Splicing factor, suppressor of white-apricot homolog (Drosophila)". Retrieved 2013-05-08.

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