TNFAIP1

TNFAIP1
Identifiers
Aliases	TNFAIP1, B12, B61, BTBD34, EDP1, hBACURD2, TNF alpha induced protein 1
External IDs	OMIM: 191161 MGI: 104961 HomoloGene: 22519 GeneCards: TNFAIP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,347,009 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,427,158 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; spleen; ; upper lobe of left lung; ; left ventricle; ; right lobe of liver; ; gallbladder; ; right lung; ; islet of Langerhans; ; body of pancreas; ; smooth muscle tissue;
	Top expressed in
	Paneth cell; ; endocardial cushion; ; fossa; ; condyle; ; ciliary body; ; medullary collecting duct; ; retinal pigment epithelium; ; internal carotid artery; ; external carotid artery; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; protein domain specific binding; identical protein binding;
Cellular component	cytoplasm; endosome; Cul3-RING ubiquitin ligase complex; nucleolus; nucleus;
Biological process	positive regulation of DNA replication; DNA replication; negative regulation of Rho protein signal transduction; protein homooligomerization; cell migration; protein ubiquitination; immune response; stress fiber assembly; proteasome-mediated ubiquitin-dependent protein catabolic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	7126
	21927
	ENSG00000109079
	ENSMUSG00000017615
	Q13829
	O70479
	NM_021137
	NM_001159392; NM_009395
	NP_066960
	NP_001152864; NP_033421
	Wikidata
View/Edit Human	View/Edit Mouse

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.^[5]^[6]^[7]

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109079 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017615 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem. 265 (5): 2973–8. doi:10.1016/S0021-9258(19)39896-5. PMID 2406243.
^ Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol. 10 (11): 5830–8. doi:10.1128/MCB.10.11.5830. PMC 361366. PMID 2233719.
^ ^a ^b "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

Further reading[edit]

Wolf FW, Marks RM, Sarma V, et al. (1992). "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene". J. Biol. Chem. 267 (2): 1317–26. doi:10.1016/S0021-9258(18)48432-3. PMID 1370465.
Pandey A, Shao H, Marks RM, et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): 567–9. Bibcode:1995Sci...268..567P. doi:10.1126/science.7536959. PMID 7536959.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Link CD, Taft A, Kapulkin V, et al. (2003). "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model". Neurobiol. Aging. 24 (3): 397–413. doi:10.1016/S0197-4580(02)00224-5. PMID 12600716. S2CID 22679483.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109079 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017615 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2406243-5] Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem. 265 (5): 2973–8. doi:10.1016/S0021-9258(19)39896-5. PMID 2406243.

[pmid2233719-6] Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol. 10 (11): 5830–8. doi:10.1128/MCB.10.11.5830. PMC 361366. PMID 2233719.

[entrez-7] "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

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