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    Thiorphan

    From Wikipedia - Reading time: 7 min
    Further information: Racecadotril
    Thiorphan
    Clinical data
    ATC code
    • none
    Identifiers
    IUPAC name
    • (±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEMBL
    Chemical and physical data
    FormulaC12H15NO3S
    Molar mass253.32 g·mol−1
    3D model (JSmol)
    ChiralityRacemic mixture
    SMILES
    • C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
    InChI
    • InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15) checkY
    • Key:LJJKNPQAGWVLDQ-UHFFFAOYSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1][2]

    References[edit]

    1. ^ a b Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology. 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640.
    2. ^ Matheson AJ, Noble S (April 2000). "Racecadotril". Drugs. 59 (4): 829–35, discussion 836–7. doi:10.2165/00003495-200059040-00010. PMID 10804038.



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