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    CD132

    From Wikipedia_zh - Reading time: 10 min

    CD132
    已知的結構
    PDB直系同源搜索: PDBe RCSB
    識別號
    别名IL2RG;, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
    外部IDOMIM:308380 MGI:96551 HomoloGene:172 GeneCards:IL2RG
    相關疾病
    X性聯嚴重複合免疫缺乏症、​combined immunodeficiency, X-linked[1]
    為以下藥物的標靶
    denileukin diftitox[2]
    基因位置(人类)
    X染色體
    染色体X染色體[3]
    X染色體
    CD132的基因位置
    CD132的基因位置
    基因座Xq13.1起始71,107,404 bp[3]
    终止71,112,108 bp[3]
    RNA表达模式
    查阅更多表达数据
    直系同源
    物種人類小鼠
    Entrez
    Ensembl
    UniProt
    mRNA​序列

    NM_000206

    NM_013563
    ​NM_001308535

    蛋白序列

    NP_000197

    NP_001295464
    ​NP_038591

    基因位置​(UCSC)Chr X: 71.11 – 71.11 MbChr X: 100.31 – 100.31 Mb
    PubMed​查找[5][6]
    維基數據
    檢視/編輯人類檢視/編輯小鼠

    CD132,又称为共用γ链Common gamma chain,缩写γc),白介素2受体γ亚基(interleukin-2 receptor subunit gamma,缩写IL-2RG)是一种细胞因子受体亚基,存在于至少六种不同的白介素受体中:包括IL-2、IL-4[7]、IL-7[8]、IL-9、IL-15[9]和IL-21的受体。γc是I型细胞因子受体家族中的一种醣蛋白,表达于大部分的淋巴细胞群体,哺乳动物的此基因位于X染色体。

    参考文献

    [编辑]
    1. ^ 與CD132相關的疾病;在維基數據上查看/編輯參考. 
    2. ^ 對Interleukin 2 receptor subunit gamma起作用的藥物;在維基數據上查看/編輯參考. 
    3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
    4. ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
    5. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
    6. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
    7. ^ Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078. 
    8. ^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077. 
    9. ^ Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440可免费查阅. PMID 7641685. 

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