Table of Contents Categories
  Encyclosphere.org ENCYCLOREADER
  supported by EncyclosphereKSF

Adenosine A2b receptor

From Wikidoc - Reading time: 5 min

Template:Wrongtitle


Adenosine A2b receptor
Identifiers
Symbols ADORA2B ; ADORA2
External IDs Template:OMIM5 Template:MGI HomoloGene: 20167
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

The adenosine A2b receptor, also known as ADORA2B, is an adenosine receptor, and also denotes the human gene incoding it.[1]

Mechanism

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene

The gene is located near the Smith-Magenis syndrome region on chromosome 17.[1]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Entrez Gene: ADORA2B adenosine A2b receptor".

Further reading[edit | edit source]

  • Stiles GL (1992). "Adenosine receptors". J. Biol. Chem. 267 (10): 6451–4. PMID 1551861.
  • Pierce KD, Furlong TJ, Selbie LA, Shine J (1992). "Molecular cloning and expression of an adenosine A2b receptor from human brain". Biochem. Biophys. Res. Commun. 187 (1): 86–93. PMID 1325798.
  • Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA (1995). "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene". Genomics. 27 (2): 374–6. doi:10.1006/geno.1995.1061. PMID 7558011.
  • Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR (1995). "Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids". Genomics. 25 (2): 605–7. PMID 7790006.
  • Strohmeier GR, Reppert SM, Lencer WI, Madara JL (1995). "The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia". J. Biol. Chem. 270 (5): 2387–94. PMID 7836474.
  • Feoktistov I, Murray JJ, Biaggioni I (1994). "Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells". Mol. Pharmacol. 45 (6): 1160–7. PMID 8022409.
  • Mirabet M, Herrera C, Cordero OJ; et al. (1999). "Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation". J. Cell. Sci. 112 ( Pt 4): 491–502. PMID 9914161.
  • Feoktistov I, Goldstein AE, Biaggioni I (1999). "Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells". Mol. Pharmacol. 55 (4): 726–34. PMID 10101031.
  • Corset V, Nguyen-Ba-Charvet KT, Forcet C; et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor". Nature. 407 (6805): 747–50. doi:10.1038/35037600. PMID 11048721.
  • Herrera C, Casadó V, Ciruela F; et al. (2001). "Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells". Mol. Pharmacol. 59 (1): 127–34. PMID 11125033.
  • Christofi FL, Zhang H, Yu JG; et al. (2001). "Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system". J. Comp. Neurol. 439 (1): 46–64. doi:10.1002/cne.1334. PMID 11579381.
  • Hayallah AM, Sandoval-Ramírez J, Reith U; et al. (2002). "1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists". J. Med. Chem. 45 (7): 1500–10. PMID 11906291.
  • Sitaraman SV, Wang L, Wong M; et al. (2002). "The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation". J. Biol. Chem. 277 (36): 33188–95. doi:10.1074/jbc.M202522200. PMID 12080047.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I (2003). "Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors". Circ. Res. 92 (5): 485–92. doi:10.1161/01.RES.0000061572.10929.2D. PMID 12600879.
  • Eltzschig HK, Ibla JC, Furuta GT; et al. (2003). "Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors". J. Exp. Med. 198 (5): 783–96. doi:10.1084/jem.20030891. PMID 12939345.
  • Ryzhov S, Goldstein AE, Matafonov A; et al. (2004). "Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma". J. Immunol. 172 (12): 7726–33. PMID 15187156.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Kolachala V, Asamoah V, Wang L; et al. (2005). "Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase". J. Biol. Chem. 280 (6): 4048–57. doi:10.1074/jbc.M409577200. PMID 15550390.
Licensed under CC BY-SA 3.0 | Source: https://www.wikidoc.org/index.php/Adenosine_A2b_receptor
23 views | Status: cached on October 25 2025 04:13:15
↧ Download this article as ZWI file
Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF