Amyloidosis epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview[edit | edit source]

The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide. The prevalence of AL amyloidosis increased significantly between 2007 and 2015, from 1.6 per 100,000 in 2007 to 4.0 per 100,000 in 2015. The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries. In amyloidosis, the mean age of presentation is 55 - 60 years. Men are more commonly affected by amyloidosis than women.

Epidemiology and Demographics[edit | edit source]

Incidence[edit | edit source]

• The incidence of amyloidosis is approximately 1.2 per 100,000 individuals per year worldwide.^[1]
• The incidence of AL amyloidosis in USA ranged from 1 per 100,000 to 1.4 per 100,000 from 2007 to 2015.^[2]
• Transthyretin-related hereditary amyloidosis is endemic in Portuguese locations Póvoa de Varzim and Vila do Conde (Caxinas), with more than 1000 affected people, coming from about 500 families, where 70% of the people develop the illness. In northern Sweden, more specifically Piteå, Skellefteå and Umeå, 1.5% of the population has the mutated gene. There are many other populations in the world who exhibit the illness after having developed it independently.

Prevalence[edit | edit source]

• The prevalence of AL in USA amyloidosis increased significantly between 2007 and 2015, from 1.6 per 100,000 in 2007 to 4.0 per 100,000 in 2015.^[3]

Mortality rate[edit | edit source]

• The mortality rate of systemic amyloidosis is approximately 100 per 100,000 deaths in developed countries.^[4]

Age[edit | edit source]

• In amyloidosis, the mean age of presentation is 55-60 years.^[5]

Race[edit | edit source]

• Hereditary amyloidosis subtypes include a substitution of an amino acid that is detected in approximately 4% of the black population.^[6]

Gender[edit | edit source]

• Men are more commonly affected by amyloidosis than women.^[7]

References[edit | edit source]

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