Antistreptococcal antibodies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview[edit | edit source]

Antistreptococcal antibodies are antibodies against a series of streptococcal exoantigens. They play a critical role in acute infections of the body surfaces, and certain organs.

Antistreptolysin O titre (AS(L)O titre or AS(L)OT) - titre of (serum) antistreptolysin O antibodies; a blood test used to assist in the diagnosis of a streptococcal infection or indicate a past exposure to streptococci. The ASOT helps direct the antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever and post infectious glomerulonephritis. The false negatives rate is 20-30%.^[1] If a false negative is suspected then an anti-DNase B titre should be sought. False positives can result from liver disease and tuberculosis.^[1]

Reference Range[edit | edit source]

Differential Diagnosis[edit | edit source]

In alphabetical order. ^{[3] [4]}

Increased Antistreptococcal Antibodies[edit | edit source]

• Acute poststreptococcal glomerulonephritis
• Chronic hepatitis
• Erysipelas
• Hyperlipidemia with obesity
• Lipid nephrosis
• Membranoproliferative glomerulonephritis
• Polyarteritis Nodosa
• Rheumatic Carditis
• Rheumatic Fever
• Scarlet Fever
• Streptococcal angina
• Streptococcal Infection
• Tuberculosis

Decreased Antistreptococcal Antibodies[edit | edit source]

• Antibody Deficiency Syndrome
• Exudative enteropathy
• Nephrotic Syndrome
• Newborns

References[edit | edit source]

Suggested Links and Web Resources[edit | edit source]

• Antistreptococcal antibody titres
• Antistreptolysin O Titer
• Antistreptolysin O Titer, Serum
• Streptococcal antibody tests

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