Aortic dissection causes

	Aortic dissection Microchapters
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Case #1
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vendhan Ramanujam M.B.B.S [2] Sahar Memar Montazerin, M.D.[3]

Overview

Atherosclerosis and hypertension are associated with spontaneous aortic dissection, while blunt trauma and sudden deceleration in a motor vehicle accident are major causes of traumatic aortic dissection.

Causes

Common Causes

The most common causes of aortic dissection include:^[1]^[2]^[3]^[4]^[5]

Causes by Organ System

Causes of aortic dissection include:^[6]^[7]^[8]^[9]^[10]^[11]^[12]^[13]^[14]

Cardiovascular	Atherosclerosis, bicuspid aortic valve, hypertension, malignant hypertension, ruptured aortic arch with aberrant left subclavian artery, seat belt aorta, vasculitis
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Methonium
Ear Nose Throat	No underlying causes
Endocrine	Cushing's syndrome
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Aneurysms osteoarthritis syndrome, annuloaortic ectasia, bicuspid aortic valve, Ehlers-Danlos syndrome, Erdheim's cystic medial necrosis, familial aortic dissection, fibromuscular dysplasia, Loeys-Dietz syndrome, Marfan syndrome, mutation of TGF-β receptor genes, mutations in genes encoding α-actin and β-myosin, mutations in SMAD3, mutations in the gene encoding filamin A, Noonan syndrome, osteogenesis imperfecta, pseudoxanthoma elasticum, Turner syndrome
Hematologic	No underlying causes
Iatrogenic	Aortic valve replacement surgery, cardiac catheterization, coronary artery bypass graft surgery, implantation of stent graft, intra-aortic balloon pump, mitral valve replacement surgery, surgical correction of aortic coarctation
Infectious Disease	AIDS, annuloaortic ectasia, aortitis, syphilitic aortitis
Musculoskeletal/Orthopedic	Ehlers-Danlos syndrome, osteogenesis imperfecta
Neurologic	No underlying causes
Nutritional/Metabolic	Homocystinuria
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Cocaine abuse
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Polycystic kidney disease
Rheumatology/Immunology/Allergy	Aortitis, arteritis, Behçet's disease, giant cell arteritis, rheumatoid arthritis, scleroderma, systemic lupus erythematosus, Takayasu arteritis, vasculitis
Sexual	No underlying causes
Trauma	Chest trauma, deceleration injuries, motor vehicle accident, seat belt aorta
Urologic	No underlying causes
Miscellaneous	Connective tissue disorders, heavy exercise, idiopathic

For more information on potential risk factors for the development of aortic dissection click here.

References

↑ Penn JL, Martindale JL, Milne LW, Marill KA (2015). "Aortic dissection associated with blunt chest trauma diagnosed by elevated D-dimer". Int J Surg Case Rep. 10: 76–9. doi:10.1016/j.ijscr.2015.03.027. PMC 4429846. PMID 25805614.
↑ Weissmann-Brenner A, Schoen R, Divon MY (2004). "Aortic dissection in pregnancy". Obstet Gynecol. 103 (5 Pt 2): 1110–3. doi:10.1097/01.AOG.0000124984.82336.43. PMID 15121626.
↑ Brooke V, Goswami S, Mohanty A, Kasi PM (2012). "Aortic dissection and renal failure in a patient with severe hypothyroidism". Case Rep Med. 2012: 842562. doi:10.1155/2012/842562. PMC 3399550. PMID 22829842.
↑ "Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group". Ophthalmology. 98 (5 Suppl): 807–22. 1991. PMID 2062514.
↑ Cury M, Zeidan F, Lobato AC (2013). "Aortic disease in the young: genetic aneurysm syndromes, connective tissue disorders, and familial aortic aneurysms and dissections". Int J Vasc Med. 2013: 267215. doi:10.1155/2013/267215. PMC 3557640. PMID 23401778.
↑ Larson, Eric W.; Edwards, William D. (1984). "Risk factors for aortic dissection: A necropsy study of 161 cases". The American Journal of Cardiology. 53 (6): 849–855. doi:10.1016/0002-9149(84)90418-1. ISSN 0002-9149.
↑ Januzzi, James L; Isselbacher, Eric M; Fattori, Rossella; Cooper, Jeanna V; Smith, Dean E; Fang, Jianming; Eagle, Kim A; Mehta, Rajendra H; Nienaber, Christoph A; Pape, Linda A (2004). "Characterizing the young patient with aortic dissection: results from the international registry of aortic dissection (IRAD)". Journal of the American College of Cardiology. 43 (4): 665–669. doi:10.1016/j.jacc.2003.08.054. ISSN 0735-1097.
↑ "Correspondence". The Annals of Thoracic Surgery. 67 (2): 593. 1999. doi:10.1016/S0003-4975(99)00037-5. ISSN 0003-4975.
↑ Losenno, Katie L.; Goodman, Robert L.; Chu, Michael W. A. (2012). "Bicuspid Aortic Valve Disease and Ascending Aortic Aneurysms: Gaps in Knowledge". Cardiology Research and Practice. 2012: 1–16. doi:10.1155/2012/145202. ISSN 2090-8016.
↑ Senaha S, Uezu T, Shimoji M, Akasaki M (March 2015). "[Stanford type B aortic dissection associated with coarctation of the aorta]". Kyobu Geka (in Japanese). 68 (3): 184–7. PMID 25743550.
↑ Dioguardi GS, Pimenta J, Knoplich J, Ghorayeb N, Ramos LR, Giannini SD (June 1994). "[Risk factors for cardiovascular diseases in physicians. Preliminary data from the VIDAM Project of the Paulista Medical Association]". Arq. Bras. Cardiol. (in Portuguese). 62 (6): 383–8. PMID 7826227.
↑ Caglayan, Ahmet Okay; Dundar, Munis (2009). "Inherited diseases and syndromes leading to aortic aneurysms and dissections". European Journal of Cardio-Thoracic Surgery. 35 (6): 931–940. doi:10.1016/j.ejcts.2009.01.006. ISSN 1010-7940.
↑ "Acute aortic dissection: pathogenesis, risk factors and diagnosis". Swiss Medical Weekly. 147 (3334). 2017. doi:10.4414/smw.2017.14489. ISSN 1424-7860.
↑ Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome.

Template:WH Template:WS CME Category::Cardiology

[pmid25805614-1] Penn JL, Martindale JL, Milne LW, Marill KA (2015). "Aortic dissection associated with blunt chest trauma diagnosed by elevated D-dimer". Int J Surg Case Rep. 10: 76–9. doi:10.1016/j.ijscr.2015.03.027. PMC 4429846. PMID 25805614.

[pmid15121626-2] Weissmann-Brenner A, Schoen R, Divon MY (2004). "Aortic dissection in pregnancy". Obstet Gynecol. 103 (5 Pt 2): 1110–3. doi:10.1097/01.AOG.0000124984.82336.43. PMID 15121626.

[pmid22829842-3] Brooke V, Goswami S, Mohanty A, Kasi PM (2012). "Aortic dissection and renal failure in a patient with severe hypothyroidism". Case Rep Med. 2012: 842562. doi:10.1155/2012/842562. PMC 3399550. PMID 22829842.

[pmid2062514-4] "Classification of diabetic retinopathy from fluorescein angiograms. ETDRS report number 11. Early Treatment Diabetic Retinopathy Study Research Group". Ophthalmology. 98 (5 Suppl): 807–22. 1991. PMID 2062514.

[pmid23401778-5] Cury M, Zeidan F, Lobato AC (2013). "Aortic disease in the young: genetic aneurysm syndromes, connective tissue disorders, and familial aortic aneurysms and dissections". Int J Vasc Med. 2013: 267215. doi:10.1155/2013/267215. PMC 3557640. PMID 23401778.

[LarsonEdwards1984-6] Larson, Eric W.; Edwards, William D. (1984). "Risk factors for aortic dissection: A necropsy study of 161 cases". The American Journal of Cardiology. 53 (6): 849–855. doi:10.1016/0002-9149(84)90418-1. ISSN 0002-9149.

[JanuzziIsselbacher2004-7] Januzzi, James L; Isselbacher, Eric M; Fattori, Rossella; Cooper, Jeanna V; Smith, Dean E; Fang, Jianming; Eagle, Kim A; Mehta, Rajendra H; Nienaber, Christoph A; Pape, Linda A (2004). "Characterizing the young patient with aortic dissection: results from the international registry of aortic dissection (IRAD)". Journal of the American College of Cardiology. 43 (4): 665–669. doi:10.1016/j.jacc.2003.08.054. ISSN 0735-1097.

[8] "Correspondence". The Annals of Thoracic Surgery. 67 (2): 593. 1999. doi:10.1016/S0003-4975(99)00037-5. ISSN 0003-4975.

[LosennoGoodman2012-9] Losenno, Katie L.; Goodman, Robert L.; Chu, Michael W. A. (2012). "Bicuspid Aortic Valve Disease and Ascending Aortic Aneurysms: Gaps in Knowledge". Cardiology Research and Practice. 2012: 1–16. doi:10.1155/2012/145202. ISSN 2090-8016.

[pmid25743550-10] Senaha S, Uezu T, Shimoji M, Akasaki M (March 2015). "[Stanford type B aortic dissection associated with coarctation of the aorta]". Kyobu Geka (in Japanese). 68 (3): 184–7. PMID 25743550.

[pmid7826227-11] Dioguardi GS, Pimenta J, Knoplich J, Ghorayeb N, Ramos LR, Giannini SD (June 1994). "[Risk factors for cardiovascular diseases in physicians. Preliminary data from the VIDAM Project of the Paulista Medical Association]". Arq. Bras. Cardiol. (in Portuguese). 62 (6): 383–8. PMID 7826227.

[CaglayanDundar2009-12] Caglayan, Ahmet Okay; Dundar, Munis (2009). "Inherited diseases and syndromes leading to aortic aneurysms and dissections". European Journal of Cardio-Thoracic Surgery. 35 (6): 931–940. doi:10.1016/j.ejcts.2009.01.006. ISSN 1010-7940.

[13] "Acute aortic dissection: pathogenesis, risk factors and diagnosis". Swiss Medical Weekly. 147 (3334). 2017. doi:10.4414/smw.2017.14489. ISSN 1424-7860.

[14] Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome.

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