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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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BCMA TALL-1 binding domain | |||||||||
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File:PDB 1oqd EBI.jpg crystal structure of stall-1 and bcma | |||||||||
Identifiers | |||||||||
Symbol | BCMA-Tall_bind | ||||||||
Pfam | PF09257 | ||||||||
InterPro | IPR015337 | ||||||||
SCOP | 1oqd | ||||||||
SUPERFAMILY | 1oqd | ||||||||
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B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.
TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).[1][2][3]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.[3]
TNFRSF17 has been shown to interact with the B-cell activating factor TNFSF13B.[4][5] A conserved domain at the N-terminus, BCMA TALL-1 binding domain, is required for binding to the TNFSF13B.[4]
TNFRSF17 is implicated in leukemia, lymphomas, and multiple myeloma [6] (see the "Mitelman Database" [7] and the Atlas of Genetics and Cytogenetics in Oncology and Haematology,[8]).
In 2017, a phase 1 clinical trial employed a CAR-T therapy that targeted BCMA02 in multiple myeloma.[9] Side-effects seen include cytokine release syndrome and mild neurotoxicity.[10]
An antibody-drug conjugate GSK2857916 is in early clinical trials.[11][12] Side effects are expected to include corneal toxicity.[12]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.