Bone marrow disorders

For congenital bone marrow disorders, click here.
For acquired bone marrow disorders, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Overview[edit | edit source]

Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.

Definition of Terms[edit | edit source]

• Bone marrow suppression: Reduced numbers of cells in the bone marrow
  • Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
  • Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)

• Bone marrow proliferation: Increased numbers of cells in the bone marrow
  • Myeloproliferation: Increased number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
  • Immunoproliferation or lymphoproliferation: Increased number of lymphoid lineage cells (T-cell, B-cell, NK cell)

Classification[edit | edit source]

Shown below is an algorithm depicting the different classes of bone marrow disorders.

References[edit | edit source]