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Bovine spongiform encephalopathy laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview[edit | edit source]
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include the detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Leystad), the detection of Scrapie-Associated Fibrils in the brain tissue (by electron microscopy), and specific histopathologic findings such as vacuolation of neurons and neuropil.
Laboratory Findings[edit | edit source]
Laboratory findings consistent with the diagnosis of bovine spongiform encephalopathy include:[1][2]
- Detection of PrPBSE in the brain tissue (either by western blot, ELISA, or ID-Lelystad)
- Vacuolation of neurons and neuropil in the histopathologic examination of medulla oblongata specimen
- Detection of Scrapie-Associated Fibrils (by electron microscopy)
References[edit | edit source]
- ↑ van Keulen LJ, Langeveld JP, Garssen GJ, Jacobs JG, Schreuder BE, Smits MA (2000). "Diagnosis of bovine spongiform encephalopathy: a review". Vet Q. 22 (4): 197–200. doi:10.1080/01652176.2000.9695057. PMID 11087129.
- ↑ "MANUAL ON BOVINE SPONGIFORM ENCEPHALOPATHY".
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