Cathepsin H, also known as CTSH, is a human gene.[1]
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.[1]
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Fuchs R, Gassen HG (1990). "Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase". Nucleic Acids Res. 17 (22): 9471. PMID2587265.
Chernaia VI, Reva AD (1990). "[Cathepsin H activity in the human brain and human brain neoplasms]". Ukr. Biokhim. Zh. 61 (5): 47–50. PMID2588347.
Fuchs R, Machleidt W, Gassen HG (1989). "Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H.". Biol. Chem. Hoppe-Seyler. 369 (6): 469–75. PMID2849458.CS1 maint: Multiple names: authors list (link)
Ritonja A, Popović T, Kotnik M; et al. (1988). "Amino acid sequences of the human kidney cathepsins H and L.". FEBS Lett. 228 (2): 341–5. PMID3342889.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Järvinen M, Rinne A (1983). "Human spleen cysteineproteinase inhibitor. Purification, fractionation into isoelectric variants and some properties of the variants". Biochim. Biophys. Acta. 708 (2): 210–7. PMID6184075.
Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. PMID7821789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Baumgrass R, Williamson MK, Price PA (1997). "Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S.". J. Bone Miner. Res. 12 (3): 447–55. PMID9076588.CS1 maint: Multiple names: authors list (link)
Söderström M, Salminen H, Glumoff V; et al. (1999). "Cathepsin expression during skeletal development". Biochim. Biophys. Acta. 1446 (1–2): 35–46. PMID10395917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Jokimaa V, Oksjoki S, Kujari H; et al. (2001). "Expression patterns of cathepsins B, H, K, L and S in the human endometrium". Mol. Hum. Reprod. 7 (1): 73–8. PMID11134363.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Uusitalo H, Hiltunen A, Söderström M; et al. (2001). "Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus". Calcif. Tissue Int. 67 (5): 382–90. PMID11136537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Pol E, Björk I (2001). "Role of the single cysteine residue, Cys 3, of human and bovine cystatin B (stefin B) in the inhibition of cysteine proteinases". Protein Sci. 10 (9): 1729–38. PMID11514663.
Waghray A, Keppler D, Sloane BF; et al. (2002). "Analysis of a truncated form of cathepsin H in human prostate tumor cells". J. Biol. Chem. 277 (13): 11533–8. doi:10.1074/jbc.M109557200. PMID11796715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Brasch F, Ten Brinke A, Johnen G; et al. (2002). "Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes". Am. J. Respir. Cell Mol. Biol. 26 (6): 659–70. PMID12034564.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Bühling F, Waldburg N, Krüger S; et al. (2003). "Expression of cathepsins B, H, K, L, and S during human fetal lung development". Dev. Dyn. 225 (1): 14–21. doi:10.1002/dvdy.10134. PMID12203716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Jenko S, Dolenc I, Guncar G; et al. (2003). "Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases". J. Mol. Biol. 326 (3): 875–85. PMID12581647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Nagai A, Terashima M, Harada T; et al. (2003). "Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis". Clin. Chim. Acta. 329 (1–2): 53–60. PMID12589965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Han SR, Momeni A, Strach K; et al. (2004). "Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis". Arterioscler. Thromb. Vasc. Biol. 23 (4): 661–7. doi:10.1161/01.ATV.0000063614.21233.BF. PMID12615673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Dodt J, Reichwein J (2004). "Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase". Biol. Chem. 384 (9): 1327–32. PMID14515996.