Cannabinoid receptor 1 (brain), also known CB1 or CNR1, is a human gene.[1]
This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.[1]
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Hoehe MR, Caenazzo L, Martinez MM; et al. (1991). "Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15". New Biol. 3 (9): 880–5. PMID1931832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Matsuda LA, Lolait SJ, Brownstein MJ; et al. (1990). "Structure of a cannabinoid receptor and functional expression of the cloned cDNA". Nature. 346 (6284): 561–4. doi:10.1038/346561a0. PMID2165569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
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Shire D, Carillon C, Kaghad M; et al. (1995). "An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing". J. Biol. Chem. 270 (8): 3726–31. PMID7876112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID8889548.CS1 maint: Multiple names: authors list (link)
Kenney SP, Kekuda R, Prasad PD; et al. (1999). "Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta". Am. J. Obstet. Gynecol. 181 (2): 491–7. PMID10454705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Porcella A, Maxia C, Gessa GL, Pani L (2000). "The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein". Eur. J. Neurosci. 12 (3): 1123–7. PMID10762343.CS1 maint: Multiple names: authors list (link)
Mukhopadhyay S, Howlett AC (2001). "CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains". Eur. J. Biochem. 268 (3): 499–505. PMID11168387.
Murphy WJ, Eizirik E, Johnson WE; et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. doi:10.1038/35054550. PMID11214319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Nong L, Newton C, Friedman H, Klein TW (2002). "CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types". Adv. Exp. Med. Biol. 493: 229–33. PMID11727770.CS1 maint: Multiple names: authors list (link)
Leroy S, Griffon N, Bourdel MC; et al. (2002). "Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1". Am. J. Med. Genet. 105 (8): 749–52. PMID11803524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Schmidt LG, Samochowiec J, Finckh U; et al. (2002). "Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence". Drug and alcohol dependence. 65 (3): 221–4. PMID11841893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Lastres-Becker I, Cebeira M, de Ceballos ML; et al. (2002). "Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets". Eur. J. Neurosci. 14 (11): 1827–32. PMID11860478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Petrelli A, Gilestro GF, Lanzardo S; et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID11894096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Huang SM, Bisogno T, Trevisani M; et al. (2002). "An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8400–5. doi:10.1073/pnas.122196999. PMID12060783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ujike H, Takaki M, Nakata K; et al. (2002). "CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia". Mol. Psychiatry. 7 (5): 515–8. doi:10.1038/sj.mp.4001029. PMID12082570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ho BY, Current L, Drewett JG (2002). "Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)". FEBS Lett. 522 (1–3): 130–4. PMID12095632.CS1 maint: Multiple names: authors list (link)
Matias I, Pochard P, Orlando P; et al. (2002). "Presence and regulation of the endocannabinoid system in human dendritic cells". Eur. J. Biochem. 269 (15): 3771–8. PMID12153574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)