Cholangiocarcinoma risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2], Suveenkrishna Pothuru, M.B,B.S. [3]

Overview[edit | edit source]

Common risk factors in the development of cholangiocarcinoma include primary sclerosing cholangitis, fibropolycystic liver disease such as choledochal cysts, hepatolithiasis and recurrent pyogenic cholangitis.

Risk Factors[edit | edit source]

• Common risk factors in the development of cholangiocarcinoma include primary sclerosing cholangitis, fibropolycystic liver disease such as choledochal cysts, hepatolithiasis and recurrent pyogenic cholangitis.

Common Risk Factors[edit | edit source]

• Common risk factors in the development of cholangiocarcinoma include:^{[1][2][3][4][5]}
  • Primary sclerosing cholangitis
  • Cirrhosis
  • Viral infections
    • HIV
    • EBV
    • Hepatitis viruses
      • Hepatitis B
      • Hepatitis C
  • Liver fluke infections
  • Hepatolithiasis
  • Choledochal cysts
  • Infusion of certain chemical agents such as naphthenic acids
  • Recurrent pyogenic cholangitis
  • Opisthorchis viverrini
  • Clonorchis sinensis
  • Caroli's disease
  • Inherited disorders
    • Lynch syndrome
    • Biliary papillomatosis

Less Common Risk Factors[edit | edit source]

• Less common risk factors in the development of cholangiocarcinoma include:^[6]
  • Thorotrast
  • Diabetes
  • Obesity
  • Alcohol consumption
  • Smoking

References[edit | edit source]

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