Chronic lymphocytic leukemia physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]

Overview[edit | edit source]

Physical examination of patients with chronic lymphocytic leukemia is usually remarkable for skin pallor, palpable cervical lymph nodes, and hepatomegaly.

Physical Examination[edit | edit source]

General Appearance[edit | edit source]

Chronic lymphocytic leukemia patients often appear cachexic with "B" symptoms (5-10%):^[1]^[2]^[3]^[4]

Skin[edit | edit source]

Pallor
Petechiae
Leukemia cutis (infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions)^[5]

HEENT[edit | edit source]

Painless lymph node enlargement (50-90%), usually cervical, supraclavicular, and axillary.
Dacryoadenitis

Abdomen[edit | edit source]

Splenomegaly (25-55%)
Hepatomegaly (15-25%)

Images[edit | edit source]

Extremity[edit | edit source]

Leukemia. Adapted from Dermatology Atlas.^[6]

Trunk[edit | edit source]

Leukemia. Adapted from Dermatology Atlas.^[6]
Leukemia. Adapted from Dermatology Atlas.^[6]
Leukemia. Adapted from Dermatology Atlas.^[6]

References[edit | edit source]

↑ Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
↑ Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
↑ Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.
↑ Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K (January 2017). "Chronic lymphocytic leukaemia". Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.
↑ Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). "Cutaneous findings in chronic lymphocytic leukaemia". Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.
↑ ^6.0 ^6.1 ^6.2 ^6.3 "Dermatology Atlas".

Template:Hematology

Template:WikiDoc Sources

[pmid29540348-1] Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.

[pmid295403482-2] Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.

[pmid1139039-3] Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.

[pmid28102226-4] Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K (January 2017). "Chronic lymphocytic leukaemia". Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.

[pmid15214899-5] Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). "Cutaneous findings in chronic lymphocytic leukaemia". Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.

[Dermatology_Atlas-6] 6.0 ^6.1 ^6.2 ^6.3 "Dermatology Atlas".

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v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy