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DGCR8 (gene)

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DiGeorge syndrome critical region gene 8
PDB rendering based on 1x47.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols DGCR8 ; C22orf12; DGCRK6; Gy1
External IDs Template:OMIM5 Template:MGI HomoloGene: 11223
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

DiGeorge syndrome critical region gene 8, also known as DGCR8, is a human gene.[1]


References[edit | edit source]

  1. ↑ "Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8".

Further reading[edit | edit source]

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Shiohama A, Sasaki T, Noda S; et al. (2003). "Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region". Biochem. Biophys. Res. Commun. 304 (1): 184–90. PMID 12705904.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
  • Gregory RI, Yan KP, Amuthan G; et al. (2004). "The Microprocessor complex mediates the genesis of microRNAs". Nature. 432 (7014): 235–40. doi:10.1038/nature03120. PMID 15531877.
  • Han J, Lee Y, Yeom KH; et al. (2005). "The Drosha-DGCR8 complex in primary microRNA processing". Genes Dev. 18 (24): 3016–27. doi:10.1101/gad.1262504. PMID 15574589.
  • Landthaler M, Yalcin A, Tuschl T (2005). "The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis". Curr. Biol. 14 (23): 2162–7. doi:10.1016/j.cub.2004.11.001. PMID 15589161.
  • Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
  • Han J, Lee Y, Yeom KH; et al. (2006). "Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex". Cell. 125 (5): 887–901. doi:10.1016/j.cell.2006.03.043. PMID 16751099.
  • Faller M, Matsunaga M, Yin S; et al. (2007). "Heme is involved in microRNA processing". Nat. Struct. Mol. Biol. 14 (1): 23–9. doi:10.1038/nsmb1182. PMID 17159994.
  • Sohn SY, Bae WJ, Kim JJ; et al. (2007). "Crystal structure of human DGCR8 core". Nat. Struct. Mol. Biol. 14 (9): 847–53. doi:10.1038/nsmb1294. PMID 17704815.

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