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Dyspnea with Normal auscultation

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]


Abbreviations: ABG (arterial blood gas); ACE (angiotensin converting enzyme); BMI (body mass index); CBC (complete blood count); CSF (cerebrospinal fluid); CXR (chest X-ray); ECG (electrocardiogram); FEF (forced expiratory flow rate); FEV1 (forced expiratory volume); FVC (forced vital capacity); JVD (jugular vein distention); MCV (mean corpuscular volume); Plt (platelet); RV (residual volume); SIADH (syndrome of inappropriate antidiuretic hormone); TSH (thyroid stimulating hormone); Vt (tidal volume); WBC (white blood cell);

Organ system Diseases Clinical manifestations Diagnosis Other features
Symptoms Physical exam
Loss of consciousness Agitation Weight loss Fever Chest pain Cough Cyanosis Clubbing JVD Peripheral edema Auscultation CBC ABG Imaging Spirometry Gold standard
Acute Dyspnea Respiratory system Head and Neck,

Upper airway

Angioedema[1] - - - - - +/- - +/- - + Normal Normal O2, ↑CO2 Normal N/A Physical exam Generalized edema
Rhinosinusitis[2] - - - + - +/- - - - - Normal WBC Normal Air fluid level Normal Physical exam Headache
Chest and Pleura,

Lower airway

Pulmonary embolism[3] - - - - + - - - - - Normal Normal Respiratory alkalosis Normal Normal Pulmonary CT angiography Pleuritic chest pain
Rib fractures (flail chest)[4] - + - - + - - - - - Normal Normal Respiratory acidosis Fracture marks Normal Chest X-ray Pneumothorax
Cardiovascular system Acute myocardial ischemia[5] +/- + - +/- + - - - - - Normal Normal Normal Normal Normal Cardiac troponin I Nausea and vomiting, Positive pertinent risk factors, such as hypertension, diabetes, and smoking
Acute heart failure[6] +/- + - - +/- + + - + + S3 Normal Respiratory alkalosis Cardiothoracic ratio Vt B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) Excessive sweating, high blood pressure
Pericardial tamponade[7] +/- - - - + - - - + - Muffled heart sounds Normal Normal Water bottle appearance enlarged heart Normal Echocardiography Fluid accumulation in pericardium
Tachyarrhythmia[5] +/- + - - +/- - - - - - High pulse rate Normal Normal Normal Normal ECG Palpitation
Central nervous system Stroke + - - +/- - - - - - - Normal Normal Normal Intracranial infarct or hemorrhage Normal Brain MRI Paralysis or paresthesia
Encephalitis[8] + + - + - - - - - - Normal WBC, neutrophilia Normal Normal Normal CSF PCR Confusion
Traumatic brain injury[9] + +/- - - - - - - - - Normal Normal Respiratory acidosis Intracerebral hemorrhage Normal Brain CT scan Lucid interval
Toxic/Metabolic Salicylate poisoning[10] + - - - - - + - - - Normal Normal Metabolic acidosis, Respiratory alkalosis Normal Normal Blood test Vomiting, Tinnitus, Confusion, Hyperthermia
Systemic Panic attack[11] +/- + - - - - - - - - Normal Normal Normal Normal Normal Clinical assessment Severe anxiety
Pregnancy[12] - - - - +/- - - - - + Normal WBC, RBC O2, ↑CO2 Normal Vt, ↑RV βhCG Missed period, Hyperemesis
Sepsis[13] +/- - - + - - - - - - Normal WBC, neutrophilia O2, ↑CO2 Normal Normal SIRS criteria Chills, Confusion
Organ system Diseases Clinical manifestations Diagnosis Other features
Symptoms Physical exam
Loss of consciousness Agitation Weight loss Fever Chest pain Cough Cyanosis Clubbing JVD Peripheral edema Auscultation CBC ABG Imaging Spirometry Gold standard
Chronic Dyspnea Respiratory system Head and Neck,

Upper airway

Goiter[14] - - - - - - - - - + Normal Normal Normal Normal Normal Blood test (TSH, T4) Weight gain
Chest and Pleura,

Lower airway

Pulmonary hypertension[15] - - - - +/- +/- +/- +/- + + Accentuated S2 Normal Hypoxia and acidosis Enlarged pulmonary arteries Physiologic RV Cardiac catheterization Syncope,

Ascites, Pleural effusion

Diaphragmatic paralysis[16] - - - +/- +/- +/- - - - - Normal Normal Normal Unilateral or bilateral diaphragmatic flattening Vt, ↑RV

(anatomical)

CXR confirmed by fluoroscopic sniff test Respiratory insufficiency
Cardiovascular system Constrictive pericarditis[7] - - - - + - - - + - Muffled heart sounds Normal Normal Calcifications  Normal Chest CT scan Syncope
Restrictive cardiomyopathy[17] - - - - + - - - - +/- Normal Normal Normal Dilatation of the inferior vena cava and right atrium Normal Right ventricular biopsy Weight gain,

Nausea

Valvular heart disease[5] - - - - + - - - - - Cardiac murmur Normal Normal Dilatation of heart chambers Normal Echocardiography Syncope, Palpitation
Bradyarrhythmia[18] - - - - - - - - - - Normal Normal Normal Normal Normal ECG Syncope, Palpitation
Pericardial effusion[19] - - - +/- + + - - + - Muffled heart sounds Normal Normal Fluid density around the heart Normal M-mode and 2-dimensional Doppler echocardiography Hoarseness, Palpitation
Coronary heart disease[5] - +/- - - + - - - - - Normal Normal O2 Normal Normal Cardiac troponin I Nausea, Lightheadedness, Sweating
Intracardiac shunt[20] - - - - +/- - + + - - Cardiac continuous murmur Normal O2 Dilatation of heart chambers Normal Echocardiography Syncope, Palpitation
Neuromuscular disease Amyotrophic lateral sclerosis[21] +/- - +/- - - - - - - - Normal WBC Normal Normal Vt, ↑RV Revised El Escorial criteria (clinical) Muscle weakness, Dysphagia
Polymyositis/dermatomyositis[22] - - +/- - + - - - - +/- Normal WBC Normal Normal Vt, ↑RV Muscle biopsy Muscle weakness, Heliotrope
Glycolytic enzyme defects (e.g., McArdle)[23] +/- - - - - - - - - +/- Normal Normal Normal Normal Vt, ↑RV Muscle biopsy (ragged red fibers) Myoglobinuria,

Muscle weakness

Toxic/Metabolic Metabolic acidosis[24] - - + - - - - - - - Normal Normal Metabolic acidosis, Respiratory alkalosis Normal Normal ABG Confusion, Vomiting
Renal failure[25] - - + - - - - - - + Normal RBC Metabolic acidosis Normal Normal Cr Nausea, Vomiting, Oliguria
Systemic Anemia[26] - - + - - - - - - - Normal RBC O2 Normal Normal HGB, MCV Weakness, Fatigue
Anxiety[27] + + + - +/- +/- - - - - Normal Normal Normal Normal Normal Psychological interview Sweating, Palpitation
Ascites[28] - - - - - - - - - - Normal Normal Normal Peritoneal fluid accumulation Vt, ↑RV Abdominal ultrasound Abdominal distention
Depression[29] - + + - - - - - - - Normal Normal Normal Normal Normal Psychological interview Depressed mood, Fatigue
Obesity[30] - - - - - - - - - - Normal Normal O2 Normal Vt, ↑RV

(anatomical)

BMI Low stamina,

Sweating

References[edit | edit source]

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