Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Synonyms and keywords: Elevated thyroid stimulating hormone, High TSH, High thyroid stimulating hormone, TSH crisis, Thyroid stimulating hormone crisis.
Various kinds of diseases that cause elevated TSH (which all are categorized as hypothyroidism) can be differentiated from each other on the basis of history and symptoms and laboratory findings:[1][2][3]
Disease | History and symptoms | Laboratory findings | Additional findings | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fever | Goiter | Pain | TSH | Free T4 | T3 | T3RU | Thyroglobin | TRH | TPOAb | |||
Primary hypothyroidism | Autoimmune | + | +/-
Diffuse |
- | ↑ | ↓ | N/↓ | Normal | N/↑ | Normal | ↑ |
|
Thyroiditis | + | +/- | + | ↑ | ↓ | Normal | Normal | N/↑ | Normal | Normal |
| |
Others | - | +/- | - | ↑ | ↓ | Normal | Normal | N/↑ | Normal | Normal |
| |
Transient hypothyroidism | +/- | - | +/- | ↑ | ↑ | Normal | Normal | ↑ | Normal | Normal |
| |
Subclinical hypothyroidism | - | - | - | ↑ | Normal | Normal | Normal | ↑ | Normal | N/↑ |
| |
Central Hypothyroidism | Pituitary | + | - | - | N/↓ | N/↓ | N/↓ | ↓ | Normal | Normal | Normal |
|
Hypothalamus | + | - | - | ↑ | Normal | ↓ | Normal |
| ||||
Resistance to TSH/TRH | - | - | - | ↑ | N/↓ | N/↓ | Normal | Normal | ↑/↓ | Normal |
|