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FASN

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Fatty acid synthase
PDB rendering based on 1xkt.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols FASN ; FAS; MGC14367; MGC15706; OA-519
External IDs Template:OMIM5 Template:MGI HomoloGene: 55800
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Fatty acid synthase, also known as FASN, is a human gene.[1]

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.[1]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Entrez Gene: FASN fatty acid synthase".

Further reading[edit | edit source]

  • Wakil SJ (1989). "Fatty acid synthase, a proficient multifunctional enzyme". Biochemistry. 28 (11): 4523–30. PMID 2669958.
  • Baron A, Migita T, Tang D, Loda M (2004). "Fatty acid synthase: a metabolic oncogene in prostate cancer?". J. Cell. Biochem. 91 (1): 47–53. doi:10.1002/jcb.10708. PMID 14689581.
  • Lejin D (1978). "[Viscosimetry in clinical practice]". Med. Pregl. 30 (9–10): 477–82. PMID 600212.
  • Wronkowski Z (1976). "[Cancer diagnosis of the respiratory system]". Pielȩgniarka i połozna (12): 7–8. PMID 1044453.
  • Jayakumar A, Tai MH, Huang WY; et al. (1995). "Human fatty acid synthase: properties and molecular cloning". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8695–9. PMID 7567999.
  • Semenkovich CF, Coleman T, Fiedorek FT (1995). "Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation". J. Lipid Res. 36 (7): 1507–21. PMID 7595075.
  • Jayakumar A, Chirala SS, Chinault AC; et al. (1995). "Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene". Genomics. 23 (2): 420–4. doi:10.1006/geno.1994.1518. PMID 7835891.
  • Kuhajda FP, Jenner K, Wood FD; et al. (1994). "Fatty acid synthesis: a potential selective target for antineoplastic therapy". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6379–83. PMID 8022791.
  • Hsu MH, Chirala SS, Wakil SJ (1996). "Human fatty-acid synthase gene. Evidence for the presence of two promoters and their functional interaction". J. Biol. Chem. 271 (23): 13584–92. PMID 8662758.
  • Pizer ES, Kurman RJ, Pasternack GR, Kuhajda FP (1997). "Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium". Int. J. Gynecol. Pathol. 16 (1): 45–51. PMID 8986532.
  • Jayakumar A, Chirala SS, Wakil SJ (1997). "Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12326–30. PMID 9356448.
  • Kusakabe T, Maeda M, Hoshi N; et al. (2000). "Fatty acid synthase is expressed mainly in adult hormone-sensitive cells or cells with high lipid metabolism and in proliferating fetal cells". J. Histochem. Cytochem. 48 (5): 613–22. PMID 10769045.
  • Ye Q, Chung LW, Li S, Zhau HE (2000). "Identification of a novel FAS/ER-alpha fusion transcript expressed in human cancer cells". Biochim. Biophys. Acta. 1493 (3): 373–7. PMID 11018265.
  • Rochat-Steiner V, Becker K, Micheau O; et al. (2000). "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation". J. Exp. Med. 192 (8): 1165–74. PMID 11034606.
  • Chirala SS, Jayakumar A, Gu ZW, Wakil SJ (2001). "Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3104–8. doi:10.1073/pnas.051635998. PMID 11248039.
  • Brink J, Ludtke SJ, Yang CY; et al. (2002). "Quaternary structure of human fatty acid synthase by electron cryomicroscopy". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 138–43. doi:10.1073/pnas.012589499. PMID 11756679.
  • Joseph SB, Laffitte BA, Patel PH; et al. (2002). "Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors". J. Biol. Chem. 277 (13): 11019–25. doi:10.1074/jbc.M111041200. PMID 11790787.
  • Ming D, Kong Y, Wakil SJ; et al. (2002). "Domain movements in human fatty acid synthase by quantized elastic deformational model". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7895–9. doi:10.1073/pnas.112222299. PMID 12060737.
  • Field FJ, Born E, Murthy S, Mathur SN (2003). "Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport". Biochem. J. 368 (Pt 3): 855–64. doi:10.1042/BJ20020731. PMID 12213084.

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