The receptors were first named in 1981 when their distribution in the CNS was determined, which was determined by Norman Bowery and his team using radioactively labelled baclofen.[3]
GABAB receptors are involved in behavioral actions of ethanol,[5]gamma-Hydroxybutyric acid (GHB),[6] and possibly in pain.[7] Recent research suggests that these receptors may play an important developmental role.[8]
↑Chen K, Li HZ, Ye N, Zhang J, Wang JJ (2005). "Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro". Brain Res Bull. 67 (4): 310–8. doi:10.1016/j.brainresbull.2005.07.004. PMID16182939.
↑Rang, H. P.; Dale, M. Maureen; Ritter, James M.; Flower, Rod J.; Henderson, Graeme (2016). Rang and Dale's Pharmacology (8th ed.). Elsevier, Churchill Livingstone. p. 462. ISBN978-0-7020-5362-7. OCLC903234097.
↑Dimitrijevic N, Dzitoyeva S, Satta R, Imbesi M, Yildiz S, Manev H (2005). "Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB)". Eur J Pharmacol. 519 (3): 246–52. doi:10.1016/j.ejphar.2005.07.016. PMID16129424.
↑Manev H, Dimitrijevic N (2004). "Drosophila model for in vivo pharmacological analgesia research". Eur J Pharmacol. 491 (2–3): 207–8. doi:10.1016/j.ejphar.2004.03.030. PMID15140638.
↑Dzitoyeva S, Gutnov A, Imbesi M, Dimitrijevic N, Manev H (2005). "Developmental role of GABAB(1) receptors in Drosophila". Brain Res Dev Brain Res. 158 (1–2): 111–4. doi:10.1016/j.devbrainres.2005.06.005. PMID16054235.
↑Purves D., Augustine G.J., Fitzpatrick D., Katz L.C., LaMantia A.S., McNamara J.O., and Williams S.M. 2001. Neuroscience, Second Edition. Sinauer Associates, Inc.
↑Kimura T, Saunders PA, Kim HS, Rheu HM, Oh KW, Ho IK (1994). "Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors". General Pharmacology. 25 (1): 193–9. doi:10.1016/0306-3623(94)90032-9. PMID8026706.
↑Froestl W, Gallagher M, Jenkins H, Madrid A, Melcher T, Teichman S, Mondadori CG, Pearlman R (October 2004). "SGS742: the first GABA(B) receptor antagonist in clinical trials". Biochemical Pharmacology. 68 (8): 1479–87. doi:10.1016/j.bcp.2004.07.030. PMID15451390.
↑Bullock R (January 2005). "SGS-742 Novartis". Current Opinion in Investigational Drugs. 6 (1): 108–13. PMID15675610.