GRAMD4

GRAM domain containing 4 is a protein that in humans is encoded by the GRAMD4 gene. ^[1]

Function[edit | edit source]

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).

Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.
Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.