Glucocorticoid resistance

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess

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Overview[edit | edit source]

Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be

Generalized or tissue-specific
Transient or permanent
Partial or complete
Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Acknowledgements[edit | edit source]

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D. Template:WH Template:WS