HIV-associated nephropathy (HIVAN) will progress to end stage renal disease (ESRD) in a few weeks to months without treatment. However, early diagnosis and treatment has shown better outcome.
Before the advent of cART therapy, the prognosis of HIV-associated nephropathy was fatal. The mortality rate during this time was 100% within 6 months.[1]
Today, the prognosis of HIVAN with the availability of cART therapy still remains grim,[1] however, treatment with cART has increased renal survival rate.[2]
Early diagnosis and Immediate treatment has shown better outcome.[1]
Treatment with cART has shown 60% reduction in the developement of HIVAN.[1]
Treatment with cART has shown 38% slowing in the progression of HIVAN towards ESRD.[1]
The current first and second year survival rate of HIV-associated nephropathy is estimated to be around 63% and 43% respectively, with the use of HAART therapy.[3]
Several factors have been associated with increased risk of progression of kidney disease in patients with HIVAN, which include:[4]