Infection

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

See also Infectious disease[edit | edit source]

Overview[edit | edit source]

An infection is the detrimental colonization of a host organism by a foreign species. In an infection, the infecting organism seeks to utilize the host's resources to multiply (usually at the expense of the host). The infecting organism, or pathogen, interferes with the normal functioning of the host and can lead to chronic wounds, gangrene, loss of an infected limb, and even death. The host's response to infection is inflammation. Colloquially, a pathogen is usually considered a microscopic organism though the definition is broader, including feces, parasites, fungi, viruses, prions, and viroids. A symbiosis between parasite and host, whereby the relationship is beneficial for the former but detrimental to the latter, is characterised as parasitism. The branch of medicine that focuses on infections and pathogens is infectious disease.

A secondary infection is an infection that occurs during or following treatment of another already existing primary infection.

Colonization[edit | edit source]

Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former would be the anaerobic bacteria species which colonize the mammalian colon, and an example of the latter would be the various species of staphylococcus which exist on human skin. Neither of these colonizations would be considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Organisms which are normally non-pathogenic can become pathogenic under the right conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing.

The variables involved in the outcome of a host becoming inoculated by a pathogen and the ultimate outcome include:

• the route of entry of the pathogen and the access to host regions that it gains
• the intrinsic virulence of the particular organism
• the quantity or load of the initial inoculant
• the immune status of the host being colonized

As an example, the staphylococcus species present on skin remain harmless on the skin, but, when present in a normally sterile space, such as in the capsule of a joint or the peritoneum, will multiply without resistance and create a huge burden on the host.

Occult infection[edit | edit source]

An occult infection is medical terminology for a "hidden" infection, that is, one which presents no symptoms. Dr. Fran Giampietro discovered this type, and coined the term "occult infection" in the late 1930s.

Identification[edit | edit source]

Scientists at Sheffield University have identified a way of using light to rapidly detect the presence of bacteria in a wound. They are developing a portable kit in which specially designed molecules emit a light signal when bound to bacteria. Current laboratory-based detection of bacteria can take hours or even days.^[1]

Causes[edit | edit source]

Drug Side Effect[edit | edit source]

• Alemtuzumab, Belimumab, Cladribine, Clocortolone pivalate, Cyclophosphamide, Epirubicin hydrochloride, Hemin, Hydrocortisone butyrate, Ifosfamide, Irinotecan hydrochloride, Megestrol, Mometasone Furoate, Nabilone, Oxaprozin, Rilonacept, Temozolomide

See also[edit | edit source]

• Antiseptic
• List of infectious diseases
• Infectious diseases
• Ubi pus, ibi evacua (Latin: "where there is pus, there evacuate it")
• Routes of infections

References[edit | edit source]

Template:Pathology

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