Iron overload disorder

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	Iron overload disorder;
ICD-10	R79.0
ICD-9	790.6

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview[edit | edit source]

In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.^[1]

Causes[edit | edit source]

The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).^[2]

Primary iron overload[edit | edit source]

Description	OMIM	Mutation
Haemochromatosis type 1: "classical"-haemochromatosis	235200	HFE
Haemochromatosis type 2A: juvenile haemochromatosis	602390	hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis	606464	hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3	604720	transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4	604653	ferroportin (SLC11A3)
Neonatal haemochromatosis	231100	(unknown)
Aceruloplasminaemia (rare disease)	604290	ceruloplasmin
Congenital atransferrinaemia (rare disease)	209300	transferrin

Secondary iron overload[edit | edit source]

Dietary iron overload
Increased intake of drugs such as ferrous gluconate.
Transfusional iron overload
Long term haemodialysis
Chronic liver disease
- Hepatitis C
- Alcoholic cirrhosis, especially when advanced
- Non-alcoholic steatohepatitis
Porphyria cutanea tarda
Post-portacaval shunting
Dysmetabolic iron overload syndrome

Miscellaneous[edit | edit source]

The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online Mendelian Inheritance in Man (OMIM) 601195)

References[edit | edit source]

↑ Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986–95. PMID 10607817.
↑ Pietrangelo A (2003). "Haemochromatosis". Gut. 52 Suppl 2: ii23–30. PMID 12651879.

External links[edit | edit source]

Template:Abnormal clinical and laboratory findings

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[1] Andrews NC (1999). "Disorders of iron metabolism". N. Engl. J. Med. 341 (26): 1986–95. PMID 10607817.

[2] Pietrangelo A (2003). "Haemochromatosis". Gut. 52 Suppl 2: ii23–30. PMID 12651879.

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