LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane.[3] In humans, this protein is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response.[4][5] LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells.[6]
Studies have linked LAMP3 with the inhibition of the viral replication of Influenza A cells.[7]
LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes.[5] LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation.[3] During human fetal development, between weeks 10 and 20, LAMP3 is highly expressed in the lungs, while in normal adult tissue cells LAMP3 is expressed in the lungs, appendix, testis and lymph nodes.[8]
↑Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y (Sep 1998). "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues". Cancer Res. 58 (16): 3499–503. PMID9721848.
de Saint-Vis B, Vincent J, Vandenabeele S, et al. (1998). "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment". Immunity. 9 (3): 325–36. doi:10.1016/S1074-7613(00)80615-9. PMID9768752.
Akasaki K, Nakamura N, Tsukui N, et al. (2004). "Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes". Arch. Biochem. Biophys. 425 (2): 147–57. doi:10.1016/j.abb.2004.02.042. PMID15111122.
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