Laryngeal cancer medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]

Overview[edit | edit source]

The medical therapy combined with radiation has largely replaced the surgical cure for laryngeal cancer. However, the treatment truly depends on the stage at the time of diagnosis. Multiple factors should be taken into account when considering treatment such as laryngeal preservation, maintaining the airway, swallowing and speech. Induction therapy includes three cycles of continuous infusion of cisplatin (100 mg/m2 on day 1) plus fluorouracil (1000 mg/m2/day) followed by definitive radiation therapy in the induction phase and concurrent consists of cisplatin (100 mg/m2 on days 1, 22, and 43) with radiation therapy.

Medical Therapy[edit | edit source]

The medical therapy combined with radiation has largely replaced the surgical cure for laryngeal cancer. However, the treatment truly depends on the stage at the time of diagnosis.^[1] Multiple factors should be taken into account when considering treatment: ^[2][3]

• Laryngeal preservation
• Maintaining the airway
• Swallowing
• Speech

Chemotherapy:[edit | edit source]

Chemotherapy consists of two phases:^[4][5]

Induction: Three cycles of continuous infusion of cisplatin (100 mg/m2 on day 1) plus fluorouracil (1000 mg/m2/day ) followed by definitive radiation therapy in the induction phase

Concurrent: Cisplatin (100 mg/m2 on days 1, 22, and 43) with radiation therapy

Radiation therapy[edit | edit source]

Radiotherapy can be very helpful in preserving the larynx and voice. It has shown similar efficacy with concomitant cisplatin as the laryngectomy-free survival ^[6][7][8]

References[edit | edit source]

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