List of bestselling drugs

The following is a list of the top 200 pharmaceutical products ranked by sales.

Rank 2006	Brand Name(s)	Generic Name	Sales 2006 (USD millions)	Change from 2005	Company(ies)	Disease/Medical Use	First Approval Date
1	Lipitor	Atorvastatin	14,385	7%	Pfizer, Astellas Pharma	Cholesterol	Dec-1996
2	Advair, Seretide	Fluticasone + Salmeterol	6,129	12%	GlaxoSmithKline	Asthma	Aug-2000
3	Plavix, Iscover	Clopidogrel	6,057	-5%	Bristol-Myers Squibb, Sanofi-Aventis	Thrombotic events	Nov-1997
4	Nexium	Esomeprazole	5,182	12%	AstraZeneca	Gastrointestinal disorders	Mar-2000
5	Norvasc	Amlodipine	4,866	3%	Pfizer	Hypertension	Jul-1992
6	Remicade	Infliximab	4,428	23%	Johnson & Johnson, Schering-Plough, Tanabe	Rheumatoid arthritis	Aug-1998
7	Enbrel	Etanercept	4,379	20%	Amgen, Wyeth	Rheumatoid arthritis	Nov-1998
8	Zyprexa	Olanzapine	4,364	4%	Eli Lilly	Schizophrenia	Sep-1996
9	Diovan	Valsartan	4,223	15%	Novartis	Hypertension	Dec-1996
10	Risperdal	Risperidone	4,183	18%	Johnson & Johnson	Schizophrenia	Dec-1993
11	Aranesp	Darbepoetin alfa	4,121	26%	Amgen	Anemia	Jun-2001
12	Rituxan, MabThera	Rituximab	3,861	16%	Roche, Genentech, Biogen Idec, Chugai Pharmaceutical	Non-Hodgkin’s lymphoma	Nov-1997
13	Effexor	Venlafaxine	3,722	8%	Wyeth	Depression	Dec-1993
14	Protonix, Pantozol, Pantoloc	Pantoprazole	3,621	4%	Wyeth, Altana, Solvay	Gastrointestinal disorders	Feb-2000
15	Singulair	Montelukast	3,579	20%	Merck & Co.	Asthma	Feb-1998
16	Seroquel	Quetiapine	3,560	23%	AstraZeneca, Astellas Pharma	Schizophrenia	Sep-1997
17	Prevacid, Takepron	Lansoprazole	3,425	3%	TAP Pharmaceuticals, Takeda Pharmaceutical	Gastrointestinal disorders	May-1995
18	Procrit, Eprex	Erythropoietin	3,180	-4%	Johnson & Johnson	Anemia	Dec-1990
19	Cozaar, Hyzaar	Losartan	3,163	4%	Merck & Co.	Hypertension	Apr-1995
20	Fosamax	Alendronate	3,134	-2%	Merck & Co.	Osteoporosis	Sep-1995
21	Herceptin	Trastuzumab	3,134	83%	Roche, Genentech, Chugai Pharmaceutical	Breast cancer	Sep-1998
22	Lovenox, Clexane	Enoxaparin	3,059	14%	Sanofi-Aventis	Deep-vein thrombosis	Mar-1993
23	Avandia, Avandamet, Avandaryl	Rosiglitazone	3,043	26%	GlaxoSmithKline	Type 2 diabetes	May-1999
24	Actos	Pioglitazone	2,880	25%	Takeda Pharmaceutical, Eli Lilly	Type 2 diabetes	Jul-1999
25	Zocor	Simvastatin	2,803	-36%	Merck & Co.	Cholesterol	Dec-1991
26	Copaxone	Glatiramer	2,757	19%	Teva Pharmaceutical Industries, Sanofi-Aventis	Multiple sclerosis	Dec-1996
27	AcipHex, Pariet	Rabeprazole	2,729	-4%	Eisai, Johnson & Johnson	Gastrointestinal disorders	Aug-1999
28	Neulasta	Filgrastim	2,710	18%	Amgen	Neutropenia	Jan-2002
29	Lexapro, Cipralex	Escitalopram	2,696	16%	Forest Laboratories, H. Lundbeck	Major depressive disorder	Aug-2002
30	Gleevec, Glivec	Imatinib	2,554	18%	Novartis	Leukemia	May-2001
31	Ambien, Stilnox	Zolpidem	2,545	33%	Sanofi-Aventis	Insomnia	Dec-1992
32	Aricept	Donepezil	2,519	24%	Eisai, Pfizer	Alzheimer’s disease	Nov-1996
33	Epogen	Erythropoietin	2,511	2%	Amgen	Anemia	Jun-1989
34	Zyrtec, Cirrus	Cetirizine	2,377	9%	Pfizer, UCB, Daiichi Sankyo	Allergic rhinitis	Dec-1995
35	Avapro, Aprovel, Avalide	Irbesartan	2,372	13%	Sanofi-Aventis, Bristol-Myers Squibb	Hypertension	Sep-1997
36	Avastin	Bevacizumab	2,364	78%	Roche, Genentech	Colorectal cancer	Feb-2004
37	Taxotere	Docetaxel	2,201	9%	Sanofi-Aventis	Cancer	Oct-1995
38	Eloxatin, Eloxatine	Oxaliplatin	2,127	8%	Sanofi-Aventis	Colorectal cancer	Aug-2002
39	Zoloft	Sertraline	2,110	-35%	Pfizer	Depression	Dec-1991
40	Tamiflu	Oseltamivir	2,096	69%	Roche, Chugai Pharmaceutical	Influenza	Oct-1999
41	Lantus	Insulin analog	2,093	37%	Sanofi-Aventis	Type 2 diabetes and type 1 diabetes	Apr-2000
42	Crestor	Rosuvastatin	2,049	61%	AstraZeneca, Shionogi	Cholesterol	Nov-2002
43	Humira	Adalimumab	2,044	46%	Abbott Laboratories	Rheumatoid arthritis	Dec-2002
44	Celebrex	Celecoxib	2,039	18%	Pfizer	Osteoarthritis and rheumatoid arthritis	Dec-1998
45	Topamax	Topiramate	2,027	21%	Johnson & Johnson	Seizures	Dec-1996
46	Prevnar	vaccine	1,961	30%	Wyeth	Pneumococcal disease	Feb-2000
47	Vytorin	Ezetimibe + Simvastatin	1,955	90%	Merck & Co., Schering-Plough	Cholesterol	Jul-2004
48	Zetia	Ezetimibe	1,929	38%	Merck & Co., Schering-Plough	Cholesterol	Oct-2002
49	Wellbutrin	Bupropion	1,926	26%	GlaxoSmithKline, Biovail	Depression	Aug-2003
50	Abilify	Aripiprazole	1,900	1%	Otsuka Pharmaceutical, Bristol-Myers Squibb	Schizophrenia	Nov-2002
51	Lamictal	Lamotrigine	1,843	19%	GlaxoSmithKline	Seizures	Dec-1994
52	Toprol, Seloken	Metoprolol	1,795	3%	AstraZeneca	Hypertension	Jan-1992
53	NeoRecormon, Epogin	Erythropoietin	1,777	-1%	Roche, Chugai Pharmaceutical	Anemia	Jul-1997
54	Atacand, Blopress	Candesartan	1,768	8%	Takeda Pharmaceutical, AstraZeneca	Hypertension	Oct-1997
55	Spiriva	Tiotropium	1,735	45%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Apr-2002
56	Avonex	Interferon beta-1a	1,707	11%	Biogen Idec	Multiple sclerosis	May-1996
57	Viagra	Sildenafil	1,657	1%	Pfizer	Erectile dysfunction	Mar-1998
58	Micardis	Telmisartan	1,645	35%	Boehringer Ingelheim, Astellas Pharma	Hypertension	Nov-1998
59	Actonel	Risedronate	1,619	-4%	Procter & Gamble, Sanofi-Aventis	Osteoporosis	Mar-1998
60	Lupron, Leuplin	Leuprolide	1,579	1%	Takeda Pharmaceutical, TAP Pharmaceuticals	Prostate cancer	Jan-1989
61	TriCor, Lipanthyl	Fenofibrate	1,567	38%	Abbott Laboratories, Solvay	Cholesterol	Feb-1998
62	Zofran	Ondansetron	1,567	3%	GlaxoSmithKline	Nausea and vomiting	Dec-1992
63	Valtrex	Valaciclovir	1,563	24%	GlaxoSmithKline	Herpes	Jun-1995
64	Levaquin, Floxin	Levofloxacin	1,530	3%	Johnson & Johnson	Bacterial infections	Dec-1996
65	Arimidex	Anastrozole	1,508	28%	AstraZeneca	Breast cancer	Dec-1995
66	Prograf	Tacrolimus	1,499	20%	Astellas Pharma	Transplant rejection	Apr-1993
67	CellCept	Mycophenolate mofetil	1,470	8%	Roche, Chugai Pharmaceutical	Transplant rejection	May-1995
68	Xalatan, Xalacom	Latanoprost	1,453	6%	Pfizer	Intraocular pressure	Jun-1996
69	Rebif	Interferon beta-1a	1,452	14%	Serono	Multiple sclerosis	Feb-1998
70	Coreg	Carvedilol	1,441	38%	GlaxoSmithKline	Hypertension	Sep-1995
71	Gemzar	Gemcitabine	1,408	5%	Eli Lilly	Cancer	May-1996
72	Prilosec, Losec	Omeprazole	1,371	-17%	AstraZeneca	Gastrointestinal disorders	Sep-1989
73	Benicar, Olmetec	Olmesartan	1,370	73%	Daiichi Sankyo, Forest Laboratories	Hypertension	Apr-2002
74	Lotrel	Amlodipine + Benazepril	1,352	26%	Novartis	Hypertension	Jun-1999
75	Cymbalta	Duloxetine	1,316	94%	Eli Lilly	Depressive disorder	Aug-2004
76	Imitrex, Imigran	Sumatriptan	1,315	4%	GlaxoSmithKline	Migraine	Dec-1992
77	Depakote	Valproate	1,308	19%	Abbott Laboratories	Seizures	Mar-1983
78	Humalog	Insulin analog	1,300	8%	Eli Lilly	Diabetes	Apr-1996
79	Duragesic	Fentanyl	1,295	-18%	Johnson & Johnson	Pain	Aug-1990
80	Pulmicort	Budesonide	1,292	11%	AstraZeneca	Asthma	Jun-1997
81	Zometa	Zoledronate	1,283	5%	Novartis	Hypercalcemia	Aug-2000
82	Betaseron, Betaferon	Interferon beta-1b	1,245	14%	Schering AG	Multiple sclerosis	Jul-1993
83	Delix, Tritace	Ramipril	1,227	-3%	Sanofi-Aventis	Hypertension	Jul-2000
84	Flovent, Flixotide	Fluticasone	1,219	5%	GlaxoSmithKline	Asthma	Mar-1996
85	Neupogen	Filgrastim	1,213	0%	Amgen	Neutropenia	Feb-1991
86	Casodex	Bicalutamide	1,206	7%	AstraZeneca	Prostate cancer	Oct-1995
87	Pravachol	Pravastatin	1,197	-47%	Bristol-Myers Squibb	Cholesterol	Oct-1991
88	Truvada	Tenofovir + Emtricitabine	1,194	110%	Gilead Sciences	HIV infection	Aug-2004
89	Symbicort	Budesonide + Formoterol	1,184	18%	AstraZeneca	Asthma	Aug-2000
90	Pegasys	Pegylated interferon alfa-2a	1,171	5%	Roche, Chugai Pharmaceutical	Hepatitis C	Jun-2002
91	Evista	Raloxifene	1,159	4%	Eli Lilly, Chugai Pharmaceutical	Osteoporosis	Dec-1997
92	Flomax	Tamsulosin	1,158	28%	Boehringer Ingelheim	Benign prostatic hypertrophy	Oct-1997
93	Lyrica	Pregabalin	1,156	297%	Pfizer	Neuropathic pain	Jul-2004
94	Paxil, Seroxat	Paroxetine	1,147	3%	GlaxoSmithKline	Depression	Dec-1992
95	Kaletra	Lopinavir	1,135	13%	Abbott Laboratories	HIV infection	Mar-2001
96	Detrol	Tolterodine	1,100	11%	Pfizer	Overactive bladder	Mar-1998
97	Harnal	Tamsulosin	1,085	-8%	Astellas Pharma	Benign prostatic hypertrophy	Jul-1992
98	Erbitux	Cetuximab	1,075	56%	Bristol-Myers Squibb, Merck KGaA	Colorectal cancer	Feb-2004
99	Synagis	Palivizumab	1,065	-9%	MedImmune	Respiratory syncytial virus	Jun-1998
100	Augmentin	Co-amoxiclav	1,055	-13%	GlaxoSmithKline	Bacterial infections	Aug-1984
101	Premarin, Prempro, Premphase	Estrogen	1,051	16%	Wyeth	Menopausal symptoms	Nov-1995
102	Ortho contraceptives	Estrogen + Progesterone	1,016	-11%	Johnson & Johnson	Contraception	Apr-1984
103	Zoladex	Goserelin	1,008	0%	AstraZeneca	Prostate cancer	Dec-1989
104	Cerezyme	Imiglucerase	1,007	8%	Genzyme	Gaucher disease	Apr-1991
105	Cravit	Levofloxacin	1,002	2%	Daiichi Sankyo, Santen Pharmaceutical	Bacterial infections	Jun-1909
106	Yasmin	Drospirenone	998	36%	Schering AG	Prevention of pregnancy	Aug-2000
107	Kogenate	Recombinant factor VIII	989	19%	Bayer	Hemophilia	Feb-1993
108	Botox	Botulin toxin	982	18%	Allergan	Cervical dystonia	Dec-1989
109	Lamisil	Terbinafine	978	-14%	Novartis	Fungal infections	Dec-1992
110	Combivir	Lamivudine + Zidovudine	977	-8%	GlaxoSmithKline	HIV infection	Sep-1997
111	Zosyn, Tazocin	Piperacillin	972	9%	Wyeth	Bacterial infections	Oct-1993
112	Cialis	Tadalafil	971	30%	Lilly, Lilly Icos	Erectile dysfunction	Nov-2002
113	Keppra	Levetiracetam	956	36%	UCB	Seizures	Nov-1999
114	NovoSeven	Factor VII	948	11%	Novo Nordisk	Bleeding due to hemophilia	Feb-1996
115	Infanrix, Pediarix	vaccine	945	21%	GlaxoSmithKline	Diphtheria, tetanus, and pertussis	Jan-1996
116	Nasonex	Mometasone	944	28%	Schering-Plough	Allergic rhinitis	Oct-1997
117	Reyataz	Atazanavir	931	34%	Bristol-Myers Squibb	HIV infection	Jan-2003
118	Concerta	Methylphenidate	930	20%	Johnson & Johnson	Attention-deficit hyperactivity disorder	Aug-2000
119	Humulin	Recombinant human insulin	925	-8%	Eli Lilly	Diabetes	Oct-1982
120	Neoral, Sandimmun	Ciclosporin	918	-4%	Novartis	Transplant rejection	Jul-1995
121	Sandostatin	Somatostatin	915	2%	Novartis	Acromegaly	Oct-1988
122	Camptosar	Irinotecan	903	-1%	Pfizer	Colorectal cancer	Jun-1996
123	Engerix-B, Havrix, Twinrix	vaccine	886	10%	GlaxoSmithKline	Hepatitis	Aug-1989
124	Allegra, Telfast	Fexofenadine	864	-49%	Sanofi-Aventis	Allergic rhinitis	Jul-1996
125	Adderall	Amphetamine	864	18%	Shire Pharmaceuticals	Attention-deficit hyperactivity disorder	Oct-2001
126	Combivent	Ipratropium + Salbutamol	843	20%	Boehringer Ingelheim	Chronic obstructive pulmonary disease	Oct-1996
127	Peg-Intron	Pegylated interferon alfa-2b	837	11%	Schering-Plough	Hepatitis C	May-2000
128	Adalat	Nifedipine	825	0%	Bayer	Hypertension	Nov-1985
129	Avelox, Avalox	Moxifloxacin	822	17%	Bayer, Schering-Plough, Shionogi	Bacterial infections	Dec-1999
130	Mobic	Meloxicam	818	-66%	Boehringer Ingelheim, Daiichi Sankyo	Osteoarthritis and rheumatoid arthritis	Feb-1996
131	Biaxin	Clarithromycin	816	-23%	Abbott Laboratories	Bacterial infections	Oct-1991
132	Mevalotin	Pravastatin	799	-35%	Daiichi Sankyo	Cholesterol	Jun-1909
133	Ultane, Sevorane	Sevoflurane	799	-9%	Abbott Laboratories	Anesthesia	Jun-1995
134	Genotropin	Somatropin	795	-2%	Pfizer	Growth failure	Aug-1995
135	Sustiva	Efavirenz	791	16%	Bristol-Myers Squibb	HIV infection	Sep-1998
136	Zyvox	Linezolid	782	27%	Pfizer	Bacterial infections	Apr-2000
137	Xeloda	Capecitabine	775	22%	Roche, Chugai Pharmaceutical	Cancer	Jun-1909
138	Geodon, Zeldox	Ziprasidone	758	29%	Pfizer	Schizophrenia	Feb-2001
139	Cipro, Ciprobay	Ciprofloxacin	755	-6%	Bayer, Schering-Plough	Bacterial infections	Oct-1987
140	Provigil	Modafinil	735	43%	Cephalon	Sleepiness	Dec-1998
141	Lescol	Fluvastatin	725	-5%	Novartis	Cholesterol	Dec-1993
142	Clarinex, Aerius	Desloratadine	722	12%	Schering-Plough	Allergic rhinitis	Dec-2001
143	Femara	Letrozole	722	35%	Novartis, Chugai Pharmaceutical	Breast cancer	Jul-1997
144	Trileptal	Oxcarbazepine	721	17%	Novartis	Seizures	Nov-1999
145	Tracleer	Bosentan	717	42%	Actelion	Pulmonary arterial hypertension	Nov-2001
146	Primaxin	Imipenem + Cilastatin	705	-5%	Merck & Co.	Bacterial infections	Nov-1985
147	Temodar	Temozolomide	703	20%	Schering-Plough	Anaplastic astrocytoma	Aug-1999
148	Trusopt, Cosopt	Dorzolamide	697	13%	Merck & Co.	Intraocular pressure	Dec-1994
149	Voltaren	Diclofenac	690	0%	Novartis	Osteoarthritis and rheumatoid arthritis	Jul-1998
150	Viread	Tenofovir	689	-12%	Gilead Sciences	HIV infection	Oct-2001
151	Sifrol	Pramipexole	673	23%	Boehringer Ingelheim	Parkinson’s disease	Oct-1997
152	Namenda	Memantine	660	30%	Forest Laboratories	Alzheimer disease	Oct-2003
153	Altace	Ramipril	653	18%	King Pharmaceuticals	Cardiovascular events	Jan-1991
154	Byetta	Exenatide	649	464%	Amylin Pharmaceuticals, Eli Lilly	Type 2 diabetes	Apr-2005
155	Tarceva	Erlotinib	649	110%	Roche, Genentech	Non-small cell lung cancer	Nov-2004
156	Zithromax, Zmax	Azithromycin	638	-68%	Pfizer	Bacterial infections	Nov-1991
157	Omnicef	Cefdinir	637	29%	Abbott Laboratories	Bacterial infections	Dec-1997
158	Proscar	Finasteride	619	-16%	Merck & Co.	Benign prostatic hypertrophy	Jun-1992
159	Alimta	Pemetrexed	612	32%	Eli Lilly	Non-small cell lung cancer	Feb-2004
160	Merrem	Meropenem	604	20%	AstraZeneca	Bacterial infections	Jun-1996
161	Forteo	Teriparatide	594	53%	Eli Lilly	Osteoporosis	Nov-2002
162	Strattera	Atomoxetine	579	5%	Eli Lilly	Attention-deficit hyperactivity disorder	Nov-2002
163	Actiq	Fentanyl	578	40%	Cephalon	Cancer pain	Nov-1998
164	Flonase, Flixonase	Fluticasone	575	-52%	GlaxoSmithKline	Allergic rhinitis	Oct-1994
165	Amaryl	Glimepiride	567	-33%	Sanofi-Aventis	Type 2 diabetes	Nov-1995
166	Lidoderm	Lidocaine	567	35%	Endo Pharmaceuticals	Pain	Mar-1999
167	Lunesta	Eszopiclone	567	72%	Sepracor	Insomnia	Dec-2004
168	Boniva, Bonviva	Ibandronate	565	454%	Roche, GlaxoSmithKline	Osteoporosis	Mar-2005
169	Taxol	Paclitaxel	563	-25%	Bristol-Myers Squibb	Cancer	Dec-1992
170	Zelnorm, Zelmac	Tegaserod	561	34%	Novartis	Irritable bowel syndrome	Mar-2002
171	Renagel	Sevelamer	559	23%	Genzyme, Roche, Chugai Pharmaceutical	Hyperphosphatemia	Oct-1998
172	Norditropin	Human growth hormone	557	19%	Novo Nordisk	Growth hormone deficiency	Jun-1909
173	Xopenex	Levalbuterol	555	29%	Sepracor	Bronchospasm	Mar-1999
174	Xenical	Orlistat	553	9%	Roche	Obesity	Jul-1998
175	Vasotec, Vaseretic	Enalapril	547	-12%	Merck & Co.	Hypertension	Dec-1985
176	Serevent	Salmeterol	538	-10%	GlaxoSmithKline	Asthma	Feb-1994
177	Cardura	Doxazosin	538	-8%	Pfizer	Hypertension	Nov-1990
178	Synthroid	Levothyroxine	534	-4%	Abbott Laboratories	Hypothyroidism	May-1909
179	Gonal-f	Follitropin alfa	533	-3%	Serono	Infertility	Oct-1995
180	Gaster	Famotidine	532	-10%	Astellas Pharma	Gastrointestinal disorders	Jun-1909
181	Cancidas	Caspofungin	530	-7%	Merck & Co.	Fungal infections	Jan-2001
182	Exelon	Rivastigmine	525	12%	Novartis	Alzheimer’s disease	May-1998
183	Vfend	Voriconazole	515	30%	Pfizer	Fungal infections	Mar-2002
184	Amlodin	Amlodipine	506	4%	Dainippon Sumitomo	Hypertension, angina pectoris	n/a
185	Niaspan	Niacin	498	13%	Kos Pharmaceuticals	Cholesterol	Jul-1997
186	Neurontin	Gabapentin	496	-22%	Pfizer	Seizures	Dec-1993
187	Trizivir	Abacavir + Lamivudine + Zidovudine	496	-10%	GlaxoSmithKline	HIV infection	Nov-2000
188	Requip	Ropinirole	496	74%	GlaxoSmithKline	Parkinson disease	Sep-1997
189	Follistim, Puregon	Follitropin beta	482	8%	Akzo Nobel	Infertility	Sep-1997
190	Basen	Voglibose	476	-13%	Takeda Pharmaceutical	Hyperglycemia	Jun-1909
191	Levitra	Vardenafil	474	19%	Bayer, GlaxoSmithKline	Erectile dysfunction	Mar-2003
192	Glucophage	Metformin	459	-16%	Merck KGaA, Bristol-Myers Squibb	Type 2 diabetes	Dec-1994
193	Concor	Bisoprolol	455	4%	Merck KGaA	Hypertension	Jul-1992
194	Epzicom, Kixeva	Abacavir + Lamivudine	446	107%	GlaxoSmithKline	HIV infection	Aug-2004
195	Xatral	Alfuzosin	443	8%	Sanofi-Aventis	Benign prostatic hypertrophy	Jan-2000
196	Diflucan	Fluconazole	435	-13%	Pfizer	Fungal infections	Jan-1990
197	Thalomid	Thalidomide	433	12%	Celgene	Erythema nodosum leprosum	Jul-1998
198	Zantac	Ranitidine	429	-18%	GlaxoSmithKline	Gastrointestinal disorders	Jun-1983
199	Xolair	Omalizumab	429	32%	Roche, Genentech	Asthma	Jun-2003
200	Claritin	Loratadine	418	-5%	Schering-Plough, Shionogi	Allergic rhinitis	Apr-1993

Source: MedAdNews 200 - World's Best-Selling Medicines, MedAdNews, July 2007