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MiR-134

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miR-134
File:Mir-134 SS.png
Conserved secondary structure of miR-134
Identifiers
Symbolmir-134
Alt. SymbolsMIR134
RfamRF00699
miRBaseMI0000474
miRBase familyMIPF0000112
Entrez406924
HUGO31519
Other data
Domain(s)Mammalia
GO0035195
SO0001244
LocusChr. 14 [1]
PDB structuresPDBe

miR-134 is a family of microRNA precursors found in mammals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-134 precursor is the microRNA mir-134.

miR-134 was one of a number of microRNAs found to be increasingly expressed in schizophrenia.[3]

Functions[edit | edit source]

miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.[4][5] In the human brain, SIRT1 is thought to mediate CREB protein through miR-134, giving the microRNA a role in higher brain functions such a memory formation.[6]

miR-134 has also been reported to function in mouse embryonic stem cells as part of a complex network regulating their differentiation.[7]

Applications[edit | edit source]

miR-134 levels in circulating blood could potentially be used as a peripheral biomarker for bipolar disorder.[8]

References[edit | edit source]

  1. ↑ Landgraf, P; Rusu, M; Sheridan, R; Sewer, A; Iovino, N; Aravin, A; Pfeffer, S; Rice, A; et al. (Jun 29, 2007). "A mammalian microRNA expression atlas based on small RNA library sequencing". Cell. 129 (7): 1401–14. doi:10.1016/j.cell.2007.04.040. PMC 2681231. PMID 17604727.
  2. ↑ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823&ndash, 826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  3. ↑ Santarelli, DM; Beveridge, NJ; Tooney, PA; Cairns, MJ (Jan 15, 2011). "Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia". Biological Psychiatry. 69 (2): 180–7. doi:10.1016/j.biopsych.2010.09.030. PMID 21111402.
  4. ↑ Schratt, GM; Tuebing, F; Nigh, EA; Kane, CG; Sabatini, ME; Kiebler, M; Greenberg, ME (Jan 19, 2006). "A brain-specific microRNA regulates dendritic spine development". Nature. 439 (7074): 283–9. doi:10.1038/nature04367. PMID 16421561.
  5. ↑ Tai, HC; Schuman, EM (Feb 21, 2006). "MicroRNA: microRNAs reach out into dendrites". Current Biology. 16 (4): R121–3. doi:10.1016/j.cub.2006.02.006. PMID 16488859.
  6. ↑ Gao, J; Wang, WY; Mao, YW; Gräff, J; Guan, JS; Pan, L; Mak, G; Kim, D; Su, SC; Tsai, LH (Aug 26, 2010). "A novel pathway regulates memory and plasticity via SIRT1 and miR-134". Nature. 466 (7310): 1105–9. doi:10.1038/nature09271. PMC 2928875. PMID 20622856.
  7. ↑ Tay, YM; Tam, WL; Ang, YS; Gaughwin, PM; Yang, H; Wang, W; Liu, R; George, J; Ng, HH; Perera, RJ; Lufkin, T; Rigoutsos, I; Thomson, AM; Lim, B (Jan 2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1". Stem Cells. 26 (1): 17–29. doi:10.1634/stemcells.2007-0295. PMID 17916804.
  8. ↑ Rong, H; Liu, TB; Yang, KJ; Yang, HC; Wu, DH; Liao, CP; Hong, F; Yang, HZ; Wan, F; Ye, XY; Xu, D; Zhang, X; Chao, CA; Shen, QJ (Jan 2011). "MicroRNA-134 plasma levels before and after treatment for bipolar mania". Journal of Psychiatric Research. 45 (1): 92–5. doi:10.1016/j.jpsychires.2010.04.028. PMID 20546789.

External links[edit | edit source]

Licensed under CC BY-SA 3.0 | Source: https://www.wikidoc.org/index.php/MiR-134
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