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NPFF

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Neuropeptide FF-amide peptide precursor
Identifiers
Symbols NPFF ; FMRFAL
External IDs Template:OMIM5 Template:MGI HomoloGene: 48236
RNA expression pattern
File:PBB GE NPFF 206402 s at tn.png
File:PBB GE NPFF 214184 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Neuropeptide FF-amide peptide precursor, also known as NPFF, is a human gene.[1]

FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function.[1]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Entrez Gene: NPFF neuropeptide FF-amide peptide precursor".

Further reading[edit | edit source]

  • Panula P, Aarnisalo AA, Wasowicz K (1996). "Neuropeptide FF, a mammalian neuropeptide with multiple functions". Prog. Neurobiol. 48 (4–5): 461–87. PMID 8804117.
  • Sundblom DM, Panula P, Fyhrquist F (1995). "Neuropeptide FF-like immunoreactivity in human plasma". Peptides. 16 (2): 347–50. PMID 7784266.
  • Perry SJ, Yi-Kung Huang E, Cronk D; et al. (1997). "A human gene encoding morphine modulating peptides related to NPFF and FMRFamide". FEBS Lett. 409 (3): 426–30. PMID 9224703.
  • Sundblom DM, Hyrkkö A, Fyhrquist F (1998). "Pulsatile secretion of neuropeptide FF into human blood". Peptides. 19 (7): 1165–70. PMID 9786165.
  • Elshourbagy NA, Ames RS, Fitzgerald LR; et al. (2000). "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor". J. Biol. Chem. 275 (34): 25965–71. doi:10.1074/jbc.M004515200. PMID 10851242.
  • Bonini JA, Jones KA, Adham N; et al. (2001). "Identification and characterization of two G protein-coupled receptors for neuropeptide FF". J. Biol. Chem. 275 (50): 39324–31. doi:10.1074/jbc.M004385200. PMID 11024015.
  • Mollereau C, Gouardères C, Dumont Y; et al. (2001). "Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226". Br. J. Pharmacol. 133 (1): 1–4. doi:10.1038/sj.bjp.0704049. PMID 11325787.
  • Catarsi S, Babinski K, Séguéla P (2001). "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF". Neuropharmacology. 41 (5): 592–600. PMID 11587714.
  • Lefrere I, De Coppet P, Camelin JC; et al. (2002). "Neuropeptide AF and FF modulation of adipocyte metabolism. Primary insights from functional genomics and effects on beta-adrenergic responsiveness". J. Biol. Chem. 277 (42): 39169–78. doi:10.1074/jbc.M205084200. PMID 12149260.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Laemmle B, Schindler M, Beilmann M; et al. (2003). "Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus". Regul. Pept. 111 (1–3): 21–9. PMID 12609745.
  • Ankö ML, Panula P (2006). "Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line". J. Neurochem. 96 (2): 573–84. doi:10.1111/j.1471-4159.2005.03581.x. PMID 16336216.
  • Roumy M, Lorenzo C, Mazères S; et al. (2007). "Physical association between neuropeptide FF and micro-opioid receptors as a possible molecular basis for anti-opioid activity". J. Biol. Chem. 282 (11): 8332–42. doi:10.1074/jbc.M606946200. PMID 17224450.

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