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National Institutes of Health Stroke Scale

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: NIH Stroke Scale; NIHSS

Overview[edit | edit source]

The National Institutes of Health Stroke Scale, or NIH Stroke Scale (NIHSS) is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke. The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment.[1] The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0.[2][3]

Score[3] Stroke Severity
0 No Stroke Symptoms
1—4 Minor Stroke
5—15 Moderate Stroke
16—20 Moderate-to-Severe Stroke
21—42 Severe Stroke











Performing the NIH Stroke Scale[edit | edit source]

Throughout the NIHSS it is important that the examiner does not coach or help with the assigned task. The examiner may demonstrate the commands to patients that are unable to comprehend verbal instructions, however the score should reflect the patient's own ability. It is acceptable for the examiner to physically help the patient get into position to begin the test, but the examiner must not provide further assistance while the patient is attempting to complete the task. For each item the examiner should score the patient's first effort, and repeated attempts should not affect the patient's score. An exception to this rule exist in the language assessment (Item 9) in which the patient's best effort should be scored.[1] Some of the items contain "Default Coma Scores", these scores are automatically assigned to patients that scored a 3 in item 1a.

1. Level of Consciousness[edit | edit source]

Level of consciousness testing is divided into three sections. The first LOC items test for the patient's responsiveness. The second LOC item is based on the patient's ability to answer questions that are verbally presented by the examiner. The final LOC sub-section is based on the patient's ability to follow verbal commands to perform simple task. Although this item is broken into three parts, each sub-section is added to the final score as if it is its own item.[3]

1A. LOC Responsiveness[edit | edit source]

Scores for this item are assigned by a medical practitioner based on the stimuli required to arouse patient. The examiner should first assess if the patient is fully alert to his or her surroundings. If the patient is not completely alert, the examiner should attempt a verbal stimuli to arouse the patient. Failure of a verbal stimuli indicates an attempt to arouse the patient via repeated physical stimuli. If none of these stimuli are successful in eliciting a response, the patient can be considered totally unresponsive.[3]

Score Test Results
0 Alert; Responsive
1 Not alert; Verbally arousable or aroused by minor stimulation to obey, answer, or respond.
2 Not alert; Only responsive to repeated or strong and painful stimuli
3 Totally unresponsive; Responds only with reflexes or is areflexic









Notes

  • If patients scores a 3 in this factor, the default coma scores should be used when applicable
1B. LOC Questions[edit | edit source]

Patient is verbally asked his or her age and for the name of the current month.[3]

Score Test Results
0 Correctly answers both questions
1 Correctly answers one question
2 Does not correctly answer either question








Notes

  • Default Coma Score: 2
  • The patient must answer each question 100% correct without help to get credit
  • Patients unable to speak are allowed to write the answer
  • Aphasic patients or patients in a stuporous state who are unable to understand the commands receive a score of 2
  • Patients that are unable to talk due to trauma, dysarthria, language barrier, or intubation are given a score of 1
1C. LOC Commands[edit | edit source]

The patient is instructed to first open and close his or her eyes and then grip and release his or her hand[3]

Score Test Results
0 Correctly performs both tasks
1 Correctly performs 1 task
2 Does not correctly perform either task








Notes

  • Commands can only be repeated once.
  • The hand grip command can be replaced with any other simple one step command if the patient cannot use his or her hands.
  • A patient's attempt is regarded as successful if an attempt is made but is incomplete due to weakness
  • If the patient does not understand the command, the command can be visually demonstrated to him or her without an impact on his or her score
  • Patients with trauma, amputations, or other physical impediments can be given other simple one-step commands if these commands are not appropriate

2. Horizontal Eye Movement[edit | edit source]

Assesses ability for patient to track a pen or finger from side to side only using his or her eyes. This is designed to assess motor ability to gaze towards the hemisphere opposite of injury. This item is tested because Conjugated eye deviation is present in approximately 20% of stroke cases. CED is more commons in right hemispheric strokes and typically in lesions effecting the basal ganglia and temporoparietal cortex. Damage to these areas can result in decreased spatial attention and reduced control of eye movements.[4]

Score Test Results
0 Normal; Able to follow pen or finger to both sides
1 Partial gaze palsy; gaze is abnormal in one or both eyes, but gaze is not totally paralyzed. Patient can gaze towards hemisphere of infarct, but can't go past midline
2 Total gaze paresis; gaze is fixed to one side








Notes

  • If patient is unable to follow the command to track an object, the investigator can make eye contact with the patient and then move side to side. The patient's gaze palsy can then be assessed by his or her ability to maintain eye contact.
  • If patient is unable to follow any commands, assess the horizontal eye movement via the oculocephalic maneuver. This is done by manually turning the patient's head from midline to one side and assessing the eye's reflex to return to a midline position.
  • If the patient has isolated peripheral nerve paresis assign a score of 1

3. Visual Field Test[edit | edit source]

Assess the patient's vision in each visual fields. Each eye is tested individually, by covering one eye and then the other. Each upper and lower quadrant is tested by asking the patient to indicate how many fingers the investigator is presenting in each quadrant. The investigator should instruct the patient to maintain eye contact throughout this test, and not allow the patient to realign focus towards each stimulus. With the first eye covered, place a random number of fingers in each quadrant and ask the patient how many fingers are being presented. Repeat this testing for the opposite eye.[3]

Score Test Results
0 No vision loss
1 Partial hemianopia or complete quadrantanopia; patient recognizes no visual stimulus in one specific quadrant
2 Complete hemianopia; patient recognizes no visual stimulus in one half of the visual field
3 Bilateral Blindness, including blindness from any cause










Notes

  • If patient is non-verbal, he or she can be allowed to respond by holding up the number of fingers the investigator is presenting
  • If patient is not responsive the visual fields can be tested by visual threat, this involves the investigator moving an object towards the eye and observing the patient's response.

4. Facial Palsy[edit | edit source]

Facial palsy is partial or complete paralysis of portions of the face. Typically this paralysis is most pronounced in the lower half of one facial side. However, depending on lesion location the paralysis may be present in other facial regions. While inspecting the symmetry of each facial expression the examiner should first instruct patient to show his or her teeth (or gums). Second, the patient should be asked to squeeze his or her eyes closed as hard as possible. After reopening his or her eyes, the patient is then instructed to raise his or her eyebrows.[5]

Score Test Results
0 Normal and symmetrical movement
1 Minor paralysis; function is less than clearly normal, such as flattened nasolabial fold or minor asymmetry in smile
2 Partial paralysis; particularly paralysis in lower face
3 Complete facial Hemiparesis, total paralysis in upper and lower portions of one face side










Notes

  • If the patient is unable to understand verbal commands, the instructions should be demonstrated to the patient.
  • Patients incapable of comprehending an commands may be tested by applying a noxious stimulus and observing for any paralysis in the resulting grimace.

5. Motor Arm[edit | edit source]

With palm facing downwards, have the patient extend one arm 90 degrees out in front if the patient is sitting, and 45 degrees out in front if the patient is lying down. If necessary, help the patient get into the correct position. As soon as the patient's arm is in position the investigator should begin verbally counting down from 10 while simultaneously counting down on his or her fingers in full view of the patient. Observe to detect any downward arm drift prior to the end of the 10 seconds. Downward movement that occurs directly after the investigator places the patient's arm in position should not be considered downward drift. Repeat this test for the opposite arm. This item should be scored for the right and left arm individually, denoted as item 5a and 5b.[3]

Score Test Results
0 No arm drift; the arm remains in the initial position for the full 10 seconds
1 Drift; the arm drifts to an intermediate position prior to the end of the full 10 seconds, but not at any point relies on a support
2 Limited effort against gravity; the arm is able to obtain the starting position, but drifts down from the initial position to a physical support prior to the end of the 10 seconds
3 No effort against gravity; the arm falls immediately after being helped to the initial position, however the patient is able to move the arm in some form (e.g. shoulder shrug)
4 No movement; patient has no ability to enact voluntary movement in this arm











Notes

  • Default Coma Score: 8
  • Test the non paralyzed arm first if applicable
  • Score should be recorded for each arm separately, resulting in a maximum potential score of 8.
  • Motor Arm assessment should be skipped in the case of an amputee, however a note should be made in the scoring of the amputation.
  • If patient is unable to understand commands, the investigator should deliver the instructions via demonstration

6. Motor Leg[edit | edit source]

With the patient in the supine position, one leg is placed 30 degrees above horizontal. As soon as the patient's leg is in position the investigator should begin verbally counting down from 5 while simultaneously counting down on his or her fingers in full view of the patient. Observe any downward leg drift prior to the end of the 5 seconds. Downward movement that occurs directly after the investigator places the patient's leg in position should not be considered downward drift. Repeat this test for the opposite leg. Scores for this section should be recorded separately as 6a and 6b for the left and right legs respectively.[3]

Score Test Results
0 No leg drift; the leg remains in the initial position for the full 5 seconds
1 Drift; the leg drifts to an intermediate position prior to the end of the full 5 seconds, but at no point touches the bed for support
2 Limited effort against gravity; the leg is able to obtain the starting position, but drifts down from the initial position to a physical support prior to the end of the 5 seconds
3 No effort against gravity; the leg falls immediately after being helped to the initial position, however the patient is able to move the leg in some form (e.g. hip flex)
4 No movement; patient has no ability to enact voluntary movement in this leg











Notes

  • Default Coma Score: 8
  • This is performed for each leg, indicating a maximum possible score of 8
  • Test the non paralyzed leg first if applicable
  • Motor leg assessment should be skipped in the case of an amputee, however a note should be made in the score records
  • If patient is unable to understand commands, the investigator should deliver the instructions via demonstration

7. Limb Ataxia[edit | edit source]

This test for the presence of a unilateral cerebellar lesion, and distinguishes a difference between general weakness and incoordination. The patient should be instructed to first touch his or her finger to the examiner's finger then move that finger back to his or her nose, repeat this movement 3-4 times for each hand. Next the patient should be instructed to move his or her heel up and down the shin of his or her opposite leg. This test should be repeated for the other leg as well.[3]

Score Test Results
0 Normal coordination; smooth and accurate movement
1 Ataxia present in 1 limb; rigid and inaccurate movement in one limb
2 Ataxia present in 2 or more limbs: rigid and inaccurate movement in both limbs on one side








Notes

  • If significant weakness is present, score 0
  • If patient is unable to understand commands or move limbs, score is 0
  • Patient's eyes should remain open throughout this section
  • If applicable, test the un-paretic side first

8. Sensory[edit | edit source]

Sensory testing is performed via pen pricks in the proximal portion of all four limbs. While applying pinpricks, the investigator should ask whether or not the patient feels the pricks, and if he or she feels the pricks differently on one side when compared to the other side.[3]

Score Test Results
0 No evidence of sensory loss
1 Mild-to-Moderate sensory loss; patient feels the pinprick, however he or she feels as if it is duller on one side
2 Severe to total sensory loss on one side; patient is not aware he or she is being touched in all unilateral extremities








Notes

  • Default Coma Score: 2
  • The investigator should insure that the sensory loss being detected is a result of the stroke, and should therefore test multiple spots on the body.
  • For patients unable to understand the instructions, the pinprick can be replaced by a noxious stimulus and the grimace can be judged to determine sensory score.

9. Language[edit | edit source]

This item measures the patient's language skills. After completing items 1-8 it is likely the investigator has gained an approximation of the patient's language skills; however it is important to confirm this measurement at this time. The stroke scale includes a picture of a picture of a scenario, a list of simple sentences, a figure of assorted random objects, and a list of words. The patient should be asked to explain the scenario depicted in the first figure. Next, he or she should read the list of sentences and name each of the objects depicted in the next figure. The scoring for this item should be based on both the results from the test performed in this item in addition to the language skills demonstrated up to this point in the stroke scale.[3]

Score Test Results
0 Normal; no obvious speech deficit
1 Mild-to-moderate aphasia; detectable loss in fluency, however, the examiner should still be able to extract information from patient's speech
2 Severe aphasia; all speech is fragmented, and examiner is unable to extract the figure's content from the patients speech.
3 Unable to speak or understand speech










Notes

  • Default Coma Score: 3
  • Patients with visual loss should be asked to identify objects placed in his or her hands
  • This is an exception to recording only the patients first attempt. In this item, the patients best language skills should be recorded

10. Speech[edit | edit source]

Dysarthria is the lack of motor skills required to produce understandable speech. Dysarthria is strictly a motor problem, and is not related to the patient's ability to comprehend speech. Strokes that cause dysarthria typically effect areas such as the anterior opercular, medial prefrontal and premotor, and anterior cingulate regions. These brain regions are vital in coordinating motor control of the tongue, throat, lips, and lungs.[6] To perform this item the patient is be asked to read from the list of words provided with the stroke scale while the examiner observes the patients articulation and clarity of speech.[3]

Score Test Results
0 Normal; clear and smooth speech
1 Mild-to-moderate dysarthria; some slurring of speech, however the patient can be understood
2 Severe dysarthria; speech is so slurred that he or she cannot be understood, or patients that cannot produce any speech








Notes

  • Default Coma Score:2
  • An intubated patient should not be rated on this item, instead make note of the situation in the scoring documents.

11. Extinction and Inattention[edit | edit source]

Sufficient information regarding this item may have been obtained by the examiner in items 1-10 to properly score the patient. However, if any ambiguity exist the examiner should test this item via a technique referred to as "double simultaneous stimulation". This is performed by having the patient close his or her eyes and asking him or her to identify the side on which they are being touched by the examiner. During this time the examiner is alternating between touching the patient on the right and left side. Next, the examiner touches the patient on both sides at the same time. This should be repeated on the patients face, arms, and legs. To test extinction in vision, the examiner should hold up one finger in front of each of the patient's eyes and ask the patient to determine which finger is wiggling or if both are wiggling. The examiner should the alternate between wiggling each finger and wiggling both fingers at the same time.[3]

Score Test Results
0 Normal; patient correctly answers all questions
1 Inattention on one side in one modality; visual, tactile, auditory, or spatial
2 Hemi-inattention; does not recognize stimuli in more than one modality on the same side








Notes

  • Default Coma Score: 0
  • Patient with severe vision loss that correctly identifies all other stimulations scores a 0

Usage[edit | edit source]

The NIHSS was designed to be a standardized and repeatable assessment of stroke patients utilized by large multi-center clinical trials.[7] Clinical researchers have widely accepted this scale due to high levels of score consistency. Consistency of NIHSS scores has been demonstrated in inter-examiner and in test-retest scenarios.[8] Clinical research use of the NIHSS typically involves obtaining a baseline NIHSS score as soon as possible after onset of stroke symptoms [9] .[10] The NIHSS is then repeated at regular intervals or after significant changes in patient condition. This history of scores can then be utilized to monitor the effectiveness of treatment methods and quantify a patient’s improvement or decline.[11][12]

NIHSS Use in tPA Eligibility[edit | edit source]

NIHSS has gained popularity as a clinical tool utilized in treatment planning. Minimum and maximum NIHSS scores have been set for multiple treatment options in order to assist physicians in choosing an appropriate treatment plan.[9][10]Tissue plasminogen activator (tPA) is currently the only proven treatment for acute ischemic strokes. Ischemic strokes are the result of blood clots that are preventing blood flow within a cerebral blood vessel. The goal of tPA treatment is to break up the clots that are occluding the vessel, and restore cerebral blood flow. Treatment with tPA has been shown to improve patient outcome, however the effectiveness of tPA is strongly correlated with the delay between stroke onset and tPA delivery. Current standards recommend for tPA to be delivered within 4.5 hours of onset, while best results occur when treatment is delivered within 90 minutes of onset.[13] Since the NIHSS has been established as a quick and consistent quantifier of stroke severity, many physicians have looked to NIHSS scores as indicators for tPA treatment. This rapid assessment of stroke severity is targeted to reduce delay of tPA treatment. Some hospitals use an NIHSS of less than 5 to exclude patients from tPA treatment, however the American Heart Association urges against NIHSS scores being used as the sole reason for declaring a patient as ineligible for tPA treatment.[14]

NIHSS Structure[edit | edit source]

In an effort to produce a complete neurological assessment the NIHSS was developed after extensive research and multiple iterations. The goal of the NIHSS was to accurately measure holistic neurological function by individually testing specific abilities. NIHSS total score is based on the summation of 4 factors. These factors are left and right motor function and left and right cortical function. The NIHSS assesses each of these specific functions by the stroke scale item listed in the chart below.[15]

Left Cortical Right Cortical Right Motor Left Motor
LOC Questions Horizontal Eye Movement Right Arm Motor Left Arm Motor
LOC Commands Visual Fields Right Leg Left Leg
Language Extinction and Inattention Dysarthria
Sensory









Accuracy[edit | edit source]

The National Institutes of Health Stroke Scale has been repeatedly validated as a tool for assessing stroke severity and as an excellent predictor for patient outcomes.[16][17][18] Severity of a stroke is heavily correlated with the volume of brain affected by the stroke, strokes effecting larger portions of the brain tend to have more detrimental effects.[19] NIHSS scores have been found to be reliable predictors of damaged brain volume, with a smaller NIHSS score indicating a smaller lesion volume[20]

Effect of stroke location on NIHSS prediction of stroke severity[edit | edit source]

Due to the NIHSS’s focus on cortical function, patients suffering from a cortical stroke tend to have higher (worse) baseline scores. The NIHSS places 7 of the possible 42 points on abilities that require verbal skills; 2 points from the LOC questions, 2 points from LOC commands, and 3 points from the Language item. The NIHSS only awards 2 points for extinction and inattention.[21] Approximately 98% of humans have verbal processing take place in the left hemisphere, indicating that the NIHSS places more value on deficits in the left hemisphere. This results in lesions receiving a higher (worse) score when occurring in the left hemisphere, compared to lesions of equal size in the right hemisphere. Due to this emphasis, the NIHSS is a better predictor of lesion volume in the strokes occurring within the left cerebral hemisphere.[14]

NIHSS as predictor of patient outcomes[edit | edit source]

The NIHSS has been found to be an excellent predictor of patient outcomes. A baseline NIHSS score greater than 16 indicates a strong probability of patient death, while a baseline NIHSS score less than 6 indicates a strong probability of a good recovery. On average, an increase of 1 point in a patient’s NIHSS score decreases the likelihood of an excellent outcome by 17%.[22] However, correlation between functional recovery and NIHSS scores was weaker when the stroke was isolated to the cortex.[20]

References[edit | edit source]

  1. ↑ 1.0 1.1 National Institute of Health, National Institute of Neurological Disorders and Stroke. Stroke Scale. http://www.ninds.nih.gov/doctors/NIH_Stroke_Scale.pdf.
  2. ↑ NIH Stroke Scale Training,Part 2. Basic Instruction. Department of Health and Human Services, National Institute of Neurological Disorders and Stroke. The National Institute of Neurological Disorders and Stroke (NINDS) Version 2.0
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 Ver Hage ,. The NIH stroke scale: a window into neurological status. Nurse.Com Nursing Spectrum (Greater Chicago) [serial online]. September 12, 2011;24(15):44-49.
  4. ↑ Singer O, Humpich M, Laufs H, Lanfermann H, Steinmetz H, Neumann-Haefelin T. Conjugate eye deviation in acute stroke: incidence, hemispheric asymmetry, and lesion pattern. Stroke; A Journal Of Cerebral Circulation [serial online]. November 2006;37(11):2726-2732. Available from: MEDLINE with Full Text, Ipswich, MA.
  5. ↑ Schimmel M, Leemann B, Christou P, Kiliaridis S, Herrmann F, Muller F. Quantitative assessment of facial muscle impairment in patients with hemispheric stroke. Journal Of Oral Rehabilitation [serial online]. n.d.;NOV, 2011, 38.11, p800-p809, 10p.
  6. ↑ Okuda B, Kawabata K, Tachibana H, Sugita M. Cerebral blood flow in pure dysarthria: role of frontal cortical hypoperfusion. Stroke; A Journal Of Cerebral Circulation [serial online]. January 1999;30(1):109-113. Available from: MEDLINE, Ipswich, MA.
  7. ↑ Brott T, Adams HP, Olinger CP, et al: Measurements of acute cerebral infarction—a clinical examination scale. Stroke 1989;20:864–70
  8. ↑ Goldstein LB, Bartels C, Davis JN. Interrater reliability of the NIH Stroke Scale. Arch Neurol. 1989;46:660–662.
  9. ↑ 9.0 9.1 Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S, for the ATLANTIS Study Investigators. Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset: the ATLANTIS study: a randomized con- trolled trial. JAMA. 1999;282:2019–2026.
  10. ↑ 10.0 10.1 del Zoppo GJ, Higashida RT, Furlan AJ, Pessin MS, Rowley HA, Gent M. PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. Stroke. 1998;29:4 –11.
  11. ↑ Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F, for the PROACT investigators. Intra-arterial prourokinase for ischemic stroke: the PROACT II study: a randomized controlled trial. JAMA. 1999;282: 2003–2011.
  12. ↑ Lewandowski CA, Frankel M, Tomsick TA, Broderick J, Frey J, Clark W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T. Combined intra- venous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke. Emergency Management of Stroke (EMS) Bridging Trial. Stroke. 1999;30:2598–2605.
  13. ↑ Eissa A, Krass I, Bajorek B. Optimizing the management of acute ischaemic stroke: a review of the utilization of intravenous recombinant tissue plasminogen activator (tPA). Journal Of Clinical Pharmacy & Therapeutics [serial online]. December 2012;37(6):620-629. Available from: CINAHL, Ipswich, MA. Accessed November 27, 2012.
  14. ↑ 14.0 14.1 Fink JN, Selim MH, Kumar S, et al: Is the association of National Institutes of Health Stroke Scale scores and acute magnetic resonance imaging stroke volume equal for pa- tients with right- and left-hemisphere ischemic stroke? Stroke 2002;33:954–8
  15. ↑ Lyden P, Lu M, Jackson C, Marler J Kothari R, Brott T, Zivin J, for the NINDS tPA Stroke Trial Investigators. Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. Stroke. 1999;30:2347–2354.
  16. ↑ Muir KW, Weir CJ, Murray GD, Povey C, Lees KR. Comparison of neurological scales and scoring systems for acute stroke prognosis. Stroke. 1996;27:1817–1820.
  17. ↑ Frankel MR, Morgenstern LB, Kwiatkowski T, Lu M, Tilley BC, Broderick JP, Libman R, Levine SR, Brott T, for the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Predicting prognosis after stroke: a placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial. Neu- rology. 2000;55:952–959.
  18. ↑ Dehaan R, Horn J, Limburg M, et al: A comparison of 5 stroke scales with measures of disability, handicap, and quality-of-life. Stroke 1993;24:1178–81
  19. ↑ Weimar C, Konig I, Kraywinkel K, Ziegler A, Diener H. Age and national institutes of health stroke scale score within 6 hours after onset are accurate predictors of outcome after cerebral ischemia - Development and external validation of prognostic models. Stroke [serial online]. n.d.;35(1):158-162. Available from: Science Citation Index, Ipswich, MA. Accessed November 19, 2012.
  20. ↑ 20.0 20.1 Glymour M, Berkman L, Ertel K, Fay M, Glass T, Furie K. Lesion characteristics, NIH Stroke Scale, and functional recovery after stroke. American Journal Of Physical Medicine & Rehabilitation [serial online]. September 2007;86(9):725-733. Available from: CINAHL, Ipswich, MA. Accessed November 27, 2012.
  21. ↑ Woo D, Broderick JP, Kothari RU, Lu M, Brott T, Lyden PD, Marler JR, Grotta JC, for the NINDS t-PA Stroke Study Group. Does the National Institutes of Health Stroke Scale favor left hemisphere strokes? Stroke. 1999;30:2355–2359.
  22. ↑ Adams H, Davis P, Hansen M, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke - A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology [serial online]. n.d.;53(1):126-131. Available from: Science Citation Index, Ipswich, MA.

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