Neurofibroma diagnostic criteria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview[edit | edit source]

Diagnostic criteria[edit | edit source]

Following is the general diagnostic criteria for neurofibroma:

• Randomly oriented thin spindled cells with wavy, hyperchromatic nuclei
  • Cellularity and organization are generally insufficient to produce palisading
  • Thin processes with indistinct cytoplasm
  • Most nuclei are small and bland
• Generally hypocellular
  • Thin and thick collagen strands (“shredded carrot collagen”)
  • Variable myxoid material surrounding cells and collagen
  • Occasional mast cells and lymphocytes, rare foam cells
• Diffusely S100 immunoreactive
• Entrapped axons of overrun nerve frequently scattered within lesion
  • Nerve frequently not grossly identifiable
• May show localized hyperchromatic atypical cells (“ancient change”)
  • Localized cells with large, pleomorphic nuclei, cytoplasmic intranuclear inclusions, smudgy chromatin, and inconspicuous nucleoli
  • Often large, long standing lesions
  • Low mitotic index

References[edit | edit source]

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