Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene .
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Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1 -mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts.
Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta -mediated activation. These paired immunoglobulin -like receptor genes are located in a tandem head-to-tail orientation on chromosome 7 . This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus , and three variants, each encoding a distinct isoform , are described.
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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