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POLL

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Polymerase (DNA directed), lambda
File:PBB Protein POLL image.jpg
PDB rendering based on 1nzp.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols POLL ; BETA-N; FLJ46002; POL-KAPPA
External IDs Template:OMIM5 Template:MGI HomoloGene: 40863
RNA expression pattern
File:PBB GE POLL 221049 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Polymerase (DNA directed), lambda, also known as POLL, is a human gene.[1]


References[edit | edit source]

  1. ↑ "Entrez Gene: POLL polymerase (DNA directed), lambda".

Further reading[edit | edit source]

  • Niida H, Nakanishi M (2002). "[A novel mammalian DNA polymerase: DNA polymerase lambda (pol lambda)]". Seikagaku. 74 (3): 224–6. PMID 11974915.
  • Nagasawa K, Kitamura K, Yasui A; et al. (2000). "Identification and characterization of human DNA polymerase beta 2, a DNA polymerase beta -related enzyme". J. Biol. Chem. 275 (40): 31233–8. doi:10.1074/jbc.M004263200. PMID 10887191.
  • García-Díaz M, Domínguez O, López-Fernández LA; et al. (2000). "DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis". J. Mol. Biol. 301 (4): 851–67. doi:10.1006/jmbi.2000.4005. PMID 10966791.
  • Aoufouchi S, Flatter E, Dahan A; et al. (2000). "Two novel human and mouse DNA polymerases of the polX family". Nucleic Acids Res. 28 (18): 3684–93. PMID 10982892.
  • García-Díaz M, Bebenek K, Kunkel TA, Blanco L (2001). "Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair". J. Biol. Chem. 276 (37): 34659–63. doi:10.1074/jbc.M106336200. PMID 11457865.
  • Haracska L, Unk I, Johnson RE; et al. (2002). "Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA". Mol. Cell. Biol. 22 (3): 784–91. PMID 11784855.
  • García-Díaz M, Bebenek K, Sabariegos R; et al. (2002). "DNA polymerase lambda, a novel DNA repair enzyme in human cells". J. Biol. Chem. 277 (15): 13184–91. doi:10.1074/jbc.M111601200. PMID 11821417.
  • Shimazaki N, Yoshida K, Kobayashi T; et al. (2003). "Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme". Genes Cells. 7 (7): 639–51. PMID 12081642.
  • Maga G, Villani G, Ramadan K; et al. (2003). "Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis". J. Biol. Chem. 277 (50): 48434–40. doi:10.1074/jbc.M206889200. PMID 12368291.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ramadan K, Maga G, Shevelev IV; et al. (2003). "Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions". J. Mol. Biol. 328 (1): 63–72. PMID 12683997.
  • Blanca G, Shevelev I, Ramadan K; et al. (2003). "Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study". Biochemistry. 42 (24): 7467–76. doi:10.1021/bi034198m. PMID 12809503.
  • Bebenek K, Garcia-Diaz M, Blanco L, Kunkel TA (2003). "The frameshift infidelity of human DNA polymerase lambda. Implications for function". J. Biol. Chem. 278 (36): 34685–90. doi:10.1074/jbc.M305705200. PMID 12829698.
  • DeRose EF, Kirby TW, Mueller GA; et al. (2003). "Solution structure of the lyase domain of human DNA polymerase lambda". Biochemistry. 42 (32): 9564–74. doi:10.1021/bi034298s. PMID 12911298.
  • Lee JW, Blanco L, Zhou T; et al. (2004). "Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts". J. Biol. Chem. 279 (1): 805–11. doi:10.1074/jbc.M307913200. PMID 14561766.
  • Shevelev I, Blanca G, Villani G; et al. (2004). "Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities". Nucleic Acids Res. 31 (23): 6916–25. PMID 14627824.
  • Guo C, Fischhaber PL, Luk-Paszyc MJ; et al. (2004). "Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis". EMBO J. 22 (24): 6621–30. doi:10.1093/emboj/cdg626. PMID 14657033.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Garcia-Diaz M, Bebenek K, Krahn JM; et al. (2004). "A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology". Mol. Cell. 13 (4): 561–72. PMID 14992725.

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