Pancreatic cancer risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview[edit | edit source]

Pancreatic cancer is associated with number of predisposing risk factors such as age, gender, ethnicity, and environmental exposures. The most potent risk factors for pancreatic cancer include smoking, alcoholism, increased BMI, diabetes mellitus, chronic pancreatitis and a family history of pancreatic cancer. Individuals with hereditary pancreatitis, familial pancreatic cancer, Peutz-Jeghers disease, familial atypical multiple mole melanoma syndrome (FAMMM), von Hippel-Lindau syndrome, multiple endocrine neoplasia type 1, cystic fibrosis of the pancreas and familial cancer syndromes such as lynch syndrome, familial adenomatous polyposis (FAP) and hereditary breast and ovarian cancer-BRCA1 and BRCA2 mutations are also at an increased risk of pancreatic cancer. Other medical conditions which pose as a risk factor for pancreatic cancer are inflammatory bowel disease, periodontal disease and peptic ulcer disease.

Risk Factors[edit | edit source]

• The most potent risk factors for pancreatic cancer include smoking, alcoholism, increased BMI, diabetes mellitus, chronic pancreatitis and a family history of pancreatic cancer.
• Individuals with the following conditions are also at an increased risk of pancreatic cancer:^[1][2][3]

• • Hereditary pancreatitis
  • Familial pancreatic cancer
  • Peutz-Jeghers disease
  • Familial atypical mole melanoma syndrome (FAMMM)
  • Cystic fibrosis of pancreas
  • Familial cancer syndromes such as:
    • Lynch syndrome
    • Familial adenomatous polyposis (FAP)
    • Von Hippel-Lindau syndrome
    • Multiple endocrine neoplasia type 1
    • Hereditary breast and ovarian cancer-BRCA1 and BRCA2 mutations

• Risk factors for Pancreatic cancer are illustrated in the following tables:

• Risk factors for Pancreatic Cancers:^[4]

• Risk Factors and Inherited Syndromes associated with Pancreatic Cancer:^[5]

References[edit | edit source]

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