Parathyroid hormone receptor

parathyroid hormone 2 receptor
Identifiers
Symbol	PTH2R
Entrez	5746
HUGO	9609
OMIM	601469
RefSeq	NM_005048
UniProt	P49190
Other data
Locus	Chr. 2 q33

parathyroid hormone 1 receptor
Identifiers
Symbol	PTH1R
Alt. symbols	PTHR, PFE
Entrez	5745
HUGO	9608
OMIM	168468
RefSeq	NM_000316
UniProt	Q03431
Other data
Locus	Chr. 3 p22-p21.1

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.^[1]

parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.^[2]^[3]
parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.^[4]

References[edit | edit source]

↑ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
↑ Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229.
↑ Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.
↑ Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.

Parathyroid+Hormone+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
"Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

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