Primary central nervous system lymphoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]

Overview[edit | edit source]

The most potent risk factor in the development of primary central nervous system lymphoma is a weakened or suppressed immune system in individuals who have acquired immunodeficiency syndrome (AIDS), received an organ transplant and are on immunosuppressants, inherited immunosuppressive disorders (IgA deficiency, Wiskott-Aldrich syndrome, ataxia telangiectasia), and autoimmune disorders (systemic lupus erythematosus, rheumatoid arthritis, myasthenia gravis).

Risk Factors[edit | edit source]

The most potent risk factor in the development of primary central nervous system lymphoma is a weakened or suppressed immune system in individuals who have:^[1]^[2]^[3]^[4]

Acquired immunodeficiency syndrome (AIDS)

The highest number of cases occur in individuals with AIDS.

Received an organ transplant and are on immunosuppressants
Inherited immunosuppressive disorder

Autoimmune disorders

References[edit | edit source]

↑ Risks of primary central nervous lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016
↑ Manenti, G.; Di Giuliano, F.; Bindi, A.; Liberto, V.; Funel, V.; Garaci, F. G.; Floris, R.; Simonetti, G. (2013). "A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/916348. ISSN 2090-6862.
↑ Epidemiology of primary CNS lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016
↑ Bhagavathi S, Wilson JD (2008). "Primary central nervous system lymphoma". Arch Pathol Lab Med. 132 (11): 1830–4. doi:10.1043/1543-2165-132.11.1830. PMID 18976024.

Template:WikiDoc Sources

[riskpcnsl1-1] Risks of primary central nervous lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016

[ManentiDi_Giuliano2013-2] Manenti, G.; Di Giuliano, F.; Bindi, A.; Liberto, V.; Funel, V.; Garaci, F. G.; Floris, R.; Simonetti, G. (2013). "A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/916348. ISSN 2090-6862.

[epidemiologyprimarycnslymphoma1-3] Epidemiology of primary CNS lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016

[pmid18976024-4] Bhagavathi S, Wilson JD (2008). "Primary central nervous system lymphoma". Arch Pathol Lab Med. 132 (11): 1830–4. doi:10.1043/1543-2165-132.11.1830. PMID 18976024.

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