Quinine Sulfate adverse reactions

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

Adverse Reactions[edit | edit source]

Overall[edit | edit source]

Quinine can adversely affect almost every body system. The most common adverse events associated with quinine use are a cluster of symptoms called "cinchonism", which occurs to some degree in almost all patients taking quinine. Symptoms of mild cinchonism include headache, vasodilation and sweating, nausea, tinnitus, hearing impairment, vertigo or dizziness, blurred vision, and disturbance in color perception. More severe symptoms of cinchonism are vomiting, diarrhea, abdominal pain, deafness, blindness, and disturbances in cardiac rhythm or conduction. Most symptoms of cinchonism are reversible and resolve with discontinuation of quinine.

The following adverse reactions have been reported with quinine sulfate. Most of these reactions are thought to be uncommon, but the actual incidence is unknown:

General[edit | edit source]

Fever, Chills, Sweating, Flushing, Asthenia, Lupus-Like Syndrome, And Hypersensitivity Reactions.

Hematologic[edit | edit source]

Agranulocytosis, Hypoprothrombinemia, Thrombocytopenia, Disseminated Intravascular Coagulation, Hemolytic Anemia; Hemolytic Uremic Syndrome , Thrombotic Thrombocytopenic Purpura, Idiopathic Thrombocytopenic Purpura, Petechiae, Ecchymosis, Hemorrhage, Coagulopathy, Blackwater Fever, Leukopenia, Neutropenia, Pancytopenia, Aplastic Anemia, And Lupus Anticoagulant.

Neuropsychiatric[edit | edit source]

Headache, Diplopia, Confusion, Altered Mental Status, Seizures, Coma, Disorientation, Tremors, Restlessness, Ataxia, Acute Dystonic Reaction, Aphasia, And Suicide.

Dermatologic[edit | edit source]

Cutaneous Rashes, Including Urticarial, Papular, Or Scarlatinal Rashes, Pruritus, Bullous Dermatitis, Exfoliative Dermatitis, Erythema Multiforme, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, Fixed Drug Eruption, Photosensitivity Reactions, Allergic Contact Dermatitis,Acral Necrosis, And Cutaneous Vasculitis.

Respiratory[edit | edit source]

Asthma, Dyspnea, Pulmonary Edema.

Cardiovascular[edit | edit source]

Chest Pain, Vasodilatation, Hypotension, Postural Hypotension, Tachycardia, Bradycardia, Palpitations, Syncope, Atrioventricular Block, Atrial Fibrillation, Irregular Rhythm, Unifocal Premature Ventricular Contractions, Nodal Escape Beats, U Waves, Qt Prolongation, Ventricular Fibrillation, Ventricular Tachycardia, Torsades De Pointes, And Cardiac Arrest.

Gastrointestinal[edit | edit source]

Nausea, Vomiting, Diarrhea, Abdominal Pain, Gastric Irritation, And Esophagitis.

Hepatobiliary[edit | edit source]

Granulomatous Hepatitis, Hepatitis, Jaundice, And Abnormal Liver Function Tests.

Metabolic[edit | edit source]

Hypoglycemia And Anorexia.

Musculoskeletal[edit | edit source]

Myalgias And Muscle Weakness.

Renal[edit | edit source]

Hemoglobinuria, Renal Failure, Renal Impairment, And Acute Interstitial Nephritis.

Special Senses[edit | edit source]

Visual Disturbances, Including Blurred Vision With Scotomata, Sudden Loss Of Vision, Photophobia, Diplopia, Night Blindness, Diminished Visual Fields, Fixed Pupillary Dilatation, Disturbed Color Vision, Optic Neuritis, Blindness, Vertigo, Tinnitus, Hearing Impairment, And Deafness.^[1]

References[edit | edit source]

Adapted from the FDA Package Insert.