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ROCK2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. [1]

Function[edit | edit source]

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References[edit | edit source]

  1. ↑ "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

Further reading[edit | edit source]

  • Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Licensed under CC BY-SA 3.0 | Source: https://www.wikidoc.org/index.php/ROCK2
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