Encyclosphere.org ENCYCLOREADER
  supported by EncyclosphereKSF

Spina bifida primary prevention

From Wikidoc - Reading time: 3 min

Spina bifida Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spina Bifida from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electroencephalogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Spina bifida primary prevention On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Spina bifida primary prevention

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Spina bifida primary prevention

CDC on Spina bifida primary prevention

Spina bifida primary prevention in the news

Blogs on Spina bifida primary prevention

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Spina bifida primary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview[edit | edit source]

A protective effect of folate against the development of neural tube defects (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century. Effective measures for the primary prevention of spina bifida include: Not drinking alcohol, not smoking, not taking drugs, taking Folic Acid and taking oral daily folate for all pregnant women. Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period. So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception. The recommended intakes of folate are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others.

Primary Prevention[edit | edit source]

  • A protective effect of folate against the development of neural tube defects (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century.[1]
  • Effective measures for the primary prevention of spina bifida include:[2]
    • Not drinking alcohol
    • Not smoking
    • Not taking drugs
    • Taking Folic Acid
  • Taking oral daily folate is recommended for all pregnant women.[1]
  • Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period.[3]
  • So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception.[3]
  • The recommended intakes of folate are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others.[1]

References[edit | edit source]

  1. 1.0 1.1 1.2 Pitkin RM (January 2007). "Folate and neural tube defects". Am. J. Clin. Nutr. 85 (1): 285S–288S. doi:10.1093/ajcn/85.1.285S. PMID 17209211.
  2. Srb V, Kubzová E (1987). "[Comparison of the effects of 1st and 3d generation platinum cytostatics on the chromosomes of lymphocytes in human peripheral blood in vitro]". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl (in Czech). 30 (4): 475–83. PMID 3504607.
  3. 3.0 3.1 Alt TH (March 1988). "Aids to scalp reduction surgery". J Dermatol Surg Oncol. 14 (3): 309–15. PMID 3279093.

Template:WH Template:WS


Licensed under CC BY-SA 3.0 | Source: https://www.wikidoc.org/index.php/Spina_bifida_primary_prevention
3 views | Status: cached on November 08 2024 07:26:40
↧ Download this article as ZWI file
Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF