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Transmembrane domain of ABC transporters

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ABC transporter transmembrane region
Identifiers
SymbolABC_membrane
PfamPF00664
InterProIPR001140
PROSITEPDOC00364
SCOP1pf4
SUPERFAMILY1pf4
TCDB3.A.1
OPM superfamily18
OPM protein1pf4

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

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ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam PF00005) have two such regions.[1].[2][3][4][5][6]

Human proteins containing this domain

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ABCB1; ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; CFTR; LOC402251; MRP3; TAP1; TAP2; TAPL; ara;

References

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  1. ↑ Kerr ID (2002). "Structure and association of ATP-binding cassette transporter nucleotide-binding domains". Biochim. Biophys. Acta. 1561 (1): -. PMID 11988180.
  2. ↑ Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). "Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter". Structure. 9 (7): -. PMID 11470432.
  3. ↑ Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). "The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter". J. Biol. Chem. 276 (34): -. PMID 11402022.
  4. ↑ Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). "Crystal structure of the ATP-binding subunit of an ABC transporter". Nature. 396 (6712): 703–707. PMID 9872322.
  5. ↑ Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). "Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis". EMBO J. 19 (22): -. PMID 11080142.
  6. ↑ Wiley DC, Gaudet R (2001). "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): -. PMID 11532960.
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