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Transmembrane protein 44

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene. [1]

Gene[edit | edit source]

mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.[2]

Locus[edit | edit source]

TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens).[3]

File:Tmem44.png
TMEM44 gene on human chromosome 3

Protein[edit | edit source]

TMEM44 is 428 amino acids in length. The molecular weight of the protein is 47.1kDa, and its formula is C2086H3315N585O611S22, with a total of 6619 atoms.[4] TMEM44 is predicted to be integrated in the plasma membrane of the endoplasmic reticulum.

Expression[edit | edit source]

There is a overall low level expression of TMEM44 protein throughout the developmental stages of an organism.[5]

Transcripts[edit | edit source]

There are 12 isoforms of TMEM44 including isoform a, isoform b, isoform c, isoform d, isoform X1, isoform X2, isoform X3, isoform X4, isoform X5, isoform X6, isoform X7, isoform X8.[3]

Transmembrane Region Allocation[edit | edit source]

There are seven predicted transmembrane domains in TMEM44 protein.

File:TMEM44 posterior probabilities.png
Phobius posterior probabilities of human TMEM44 protein

Interacting Proteins[edit | edit source]

GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.[6][7][8]

Post-Translational Modification[edit | edit source]

TMEM44 is predicted to undergo threonine, tyrosine and serine phosphorylations.[9]

File:TMEM44 Phospho.png
Predicted phosphorylation sites in human TMEM44 protein

Orthologs[edit | edit source]

TMEM44 orthologs includes groups such as amphibians, birds, fish, mammals.[10]

Paralogs[edit | edit source]

Predicted paralogous proteins of TMEM44 are C9IZ85, F8WCY1, F8WE47, H7C3X7, J3KQW3, Q6PL43, and Q96I73.[11]

References[edit | edit source]

  1. ↑ "Entrez Gene: Transmembrane protein 44". Retrieved 2018-05-01.
  2. ↑ "Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-18.
  3. ↑ 3.0 3.1 "TMEM44 transmembrane protein 44 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-15.
  4. ↑ "ExPASy - ProtParam tool". web.expasy.org. Retrieved 2018-04-22.
  5. ↑ Group, Schuler. "EST Profile - Hs.478729". www.ncbi.nlm.nih.gov. Retrieved 2018-04-23.
  6. ↑ IntAct. "https://www.ebi.ac.uk/intact/". www.ebi.ac.uk. Retrieved 2018-04-22. External link in |title= (help)
  7. ↑ Lab, Mike Tyers. "BioGRID | Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Retrieved 2018-04-22.
  8. ↑ "The Molecular INTeraction Database – An ELIXIR Core Resource". mint.bio.uniroma2.it. Retrieved 2018-04-22.
  9. ↑ "NetPhos 3.1 Server". www.cbs.dtu.dk. Retrieved 2018-04-22.
  10. ↑ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2018-02-18.
  11. ↑ Database, GeneCards Human Gene. "TMEM44 Gene - GeneCards | TMM44 Protein | TMM44 Antibody". www.genecards.org. Retrieved 2018-04-23.

Further reading[edit | edit source]


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