Tris(2-chloroethyl)amine

	WikiDoc Resources for Tris(2-chloroethyl)amine
Articles
Most recent articles on Tris(2-chloroethyl)amine Most cited articles on Tris(2-chloroethyl)amine Review articles on Tris(2-chloroethyl)amine Articles on Tris(2-chloroethyl)amine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Tris(2-chloroethyl)amine Images of Tris(2-chloroethyl)amine Photos of Tris(2-chloroethyl)amine Podcasts & MP3s on Tris(2-chloroethyl)amine Videos on Tris(2-chloroethyl)amine
Evidence Based Medicine
Cochrane Collaboration on Tris(2-chloroethyl)amine Bandolier on Tris(2-chloroethyl)amine TRIP on Tris(2-chloroethyl)amine
Clinical Trials
Ongoing Trials on Tris(2-chloroethyl)amine at Clinical Trials.gov Trial results on Tris(2-chloroethyl)amine Clinical Trials on Tris(2-chloroethyl)amine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tris(2-chloroethyl)amine NICE Guidance on Tris(2-chloroethyl)amine NHS PRODIGY Guidance FDA on Tris(2-chloroethyl)amine CDC on Tris(2-chloroethyl)amine
Books
Books on Tris(2-chloroethyl)amine
News
Tris(2-chloroethyl)amine in the news Be alerted to news on Tris(2-chloroethyl)amine News trends on Tris(2-chloroethyl)amine
Commentary
Blogs on Tris(2-chloroethyl)amine
Definitions
Definitions of Tris(2-chloroethyl)amine
Patient Resources / Community
Patient resources on Tris(2-chloroethyl)amine Discussion groups on Tris(2-chloroethyl)amine Patient Handouts on Tris(2-chloroethyl)amine Directions to Hospitals Treating Tris(2-chloroethyl)amine Risk calculators and risk factors for Tris(2-chloroethyl)amine
Healthcare Provider Resources
Symptoms of Tris(2-chloroethyl)amine Causes & Risk Factors for Tris(2-chloroethyl)amine Diagnostic studies for Tris(2-chloroethyl)amine Treatment of Tris(2-chloroethyl)amine
Continuing Medical Education (CME)
CME Programs on Tris(2-chloroethyl)amine
International
Tris(2-chloroethyl)amine en Espanol Tris(2-chloroethyl)amine en Francais
Business
Tris(2-chloroethyl)amine in the Marketplace Patents on Tris(2-chloroethyl)amine
Experimental / Informatics
List of terms related to Tris(2-chloroethyl)amine

Template:Chembox header\| Tris(2-chloroethyl)amine
Tris(2-chloroethyl)amine Tris(2-chloroethyl)amine
Chemical name	2-chloro-N,N-bis(2-chloroethyl)ethanamine
Other names	HN3, Compound 9560 Nitrogen mustard gas; tris-(2-chloroethyl)amine trichlormethine; trimustine hydrochloride
Chemical formula	C₆H₁₂Cl₃N
Molecular mass	204.53 g mol⁻¹
CAS number	[555-77-1]
Density	1.24 g/cm³
Melting point	-3.7 to -4°C
Boiling point	143 °C
SMILES	ClCCN(CCCl)CCCl
Template:Chembox header \| Disclaimer and references

Overview[edit | edit source]

Tris(2-chloroethyl)ethylamine is the organic compound with the formula N(CH₂CH₂Cl)₃. Often abbreviated HN3, it is a powerful blister agent and a so-called nitrogen mustard gas (it is not a gas) used for chemical warfare. HN-3 was the last of the nitrogen mustard agents developed. It was designed as a military agent and is the only one of the nitrogen mustards that is still used for military purposes. It is the principal representative of the nitrogen mustards because its vesicant properties are almost equal to those of HD.

Mode of action[edit | edit source]

Nitrogen mustards react via an initial cyclization to the corresponding iminium salt. The rate of this reaction is pH dependent because the protonated amine cannot cyclize.

Applications[edit | edit source]

HN-3 has found some applications in chemotherapy, e.g. for Hodgkin's disease, but it is mainly of interest for its military uses and is the only one of these agents that remains anywhere as a military agent. These agents are more immediately toxic than the sulfur mustards.

Safety[edit | edit source]

Like other chemical warfare agents, tris92-chloroethyl)amine is highly toxic.

Template:Chemical warfare Template:WH Template:WS