Vitamin D deficiency laboratory findings

There is no consensus on the serum 25-hydroxyvitamin D levels, "25(OH)D", considered "normal". 12 ng per milliliter (50 nmol per liter) ihas been proposed.^[1] However, "a common misconception is that the RDA functions as a “cut point” and that nearly the entire population must have a serum 25(OH)D level above 20 ng per milliliter to achieve good bone health. The reality is that the majority (about 97.5%) of the population has a requirement of 20 ng per milliliter or less. Moreover, by definition of an average requirement, approximately half the population has a requirement of 16 ng per milliliter (the EAR) or less. " (italics added)^[1] Previous opinions suggested a value equal or less than 20 ng per milliliter (50 nmol per liter) is in the deficient range.^{[2], [3], [4], [5]}

The definition can be based on the point at which the parathyroid hormone (PTH) levels off as the cutoff point, which may be at 12 ng per milliliter (30 nmol per liter)^[6] or is close to 30 ng per milliliter (75 nmol per liter). ^[7]

The Institute of Medicine states (page 13): ^[8]* Levels over 20 ng/ml: "Practically all persons are sufficient"

• Levels 12-20 ng/ml (<50 nmol/L): "Some, but not all, persons are potentially at risk for inadequacy."
• Levels below 12 ng/m (< 30 nmol/L): "persons are at risk of deficiency."

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