In May 2018, governor of Rivne Oblast Oleksiy Mulyarenko and commander of Operational Command West Major General Oleksandr Pavlyuk were tasked with control of creation of Brigade.[2] Tsys Oleksandr became first commander of the Brigade. He announced that brigade will have about 3500 troops, mostly reservists, who will have yearly training exercises.[3] On 27 June 2018 the brigade was formed in Rivne Oblast.[4]
In November 2018, between 200 and 300 reservists from Varash and 9 neighboring raions, gathered at a shooting range. Also they conducted tactical, medical and engineering exercises.[5] In December, Brigade along with neighboring brigades, held joint combat readiness exercises conducted by join Ukrainian and British instructors.[6]
Between 17-23 May 2019, Brigade held staff officer exercises. They included planning combat and special operations, marches, supply issues.[1][7]
On 8 October 2019, 61st Territorial Defense Battalion held combat readiness exercise for more than 200 soldiers.[8]
From 22 to 30 September 2021, strategic command and staff exercises Joint Efforts-2021 were held in Ukraine. Brigade took part in it along with about 12,500 troops and troops from 15 countries, including 11 NATO member countries.[9]
2 days after invasion, more than 1000 people joined the Brigade.[10]
As Belarusian Armed Forces continue exercises near Ukrainian border, on 8 June 2022 units of brigade held exercisers on how to capture a convoy and how to defend against enemy ambush.[11]
On 6 June 2023 Colonel Oleksandr Tsys was replaced by Lieutenant Colonel Serhii Kasprov who previously commanded 251st Territorial Defense Battalion.[12]
During June 2023, the brigade's 60th Battalion participated in combat operations near the village of Ozarianivka near Bakhmut.[13]
In mid-September 2024, units of the 104th Brigade reportedly participated in a battle in the village of Obukhovka [ru], as part of the Ukrainian operation in Russia's Kursk Oblast.[14]
^ ab"Навчальні збори офіцерів запасу" [Training meeting of reserve officers]. Varash City Council (in Ukrainian). 30 May 2019. Archived from the original on 18 August 2019. Retrieved 18 August 2019.