On 27 June 2018, the brigade was formed Khmelnytskyi Oblast.[1][2] The brigade was planned to be composed of older reservists, with more than 2,000 of 41-50 year olds signing up.[3] By November 2018, battalions were actively recruiting reservists.[4]
In August 2019, the brigade held an exercise for 154 officers to increase the overall efficiency of defending critical infrastructure, countering sabotage and reconnaissance units, and waging battles in cities and forests.[5][6]
By mid-February 2022, the Territorial Defense Battalion from Starokostiantyniv had filled 74% of its positions for officers, sergeants and soldiers.[7] At the same time, residents of Slavuta began to organize their own battalion to add to those already serving in the Brigade.[8]
Units of the brigade took part in the recapture of Lyman, losing 9 soldiers.[9]
In November, the 88th battalion from Shepetivka was serving in areas of Bakhmut and Sloviansk.[10] On 5 December, the brigade's battle flag was created.[1] Units of the brigade were deployed on the Zaporizhzhia frontline between Huliaipole-Polohy in December.[11] In April 2024, reconnaissance units of the brigade were reported to be defending positions on the Russia–Ukraine border in the Sumy Oblast.[12]